Gastrointestinal perforation occurs when the wall of the stomach, small intestine or large bowel develops a hole through its entire thickness. Perforation of the intestine leads to leakage of intestinal contents into the abdominal cavity. This causes an inflammation called peritonitis. Perforation anywhere along the gastrointestinal tract is a surgical emergency. Below you may find medications used to treat or help with Gastrointestinal Perforation. More about Gastrointestinal Perforation