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Feldene (Piroxicam) Buyer and Patient Handbook in South Africa

About Feldene

Feldene is the trade name for piroxicam, a non-steroidal anti-inflammatory drug (NSAID) used to relieve Pain and inflammation. It belongs to the NSAID class and is commonly prescribed for Osteoarthritis, Rheumatoid Arthritis and postoperative discomfort. The product is authorised by the South African Health Products Regulatory Authority (SAHPRA) and is available in oral tablet form.

Ideal Candidates

• Adults experiencing mild-to-moderate musculoskeletal pain.
• Patients with osteoarthritis or rheumatoid arthritis requiring anti-inflammatory therapy.
• Individuals recovering from minor surgical procedures where swelling is expected.
• People who prefer a once-daily dosing schedule.

Mechanism of Action

Feldene works by selectively inhibiting cyclo-oxygenase (COX) enzymes, which reduces the production of prostaglandins that cause pain and swelling. Think of prostaglandins as the alarm system that signals injury; Feldene turns down the volume, allowing normal activity to resume. Abuse potential is negligible, but the drug can cause gastrointestinal irritation if misused.

Benefits of Feldene

The long half-life of piroxicam (≈ 50 hours) means patients often need only one dose per day, improving adherence. Generic versions are financially accessible, while the branded product maintains consistent quality and packaging. Off-label uses such as treating certain skin conditions should only be considered after professional consultation.

Dosage Recommendations

Recommended Dosage

• 10 mg tablet: take one tablet once daily.
• 20 mg tablet: take one tablet once daily for severe inflammation, as directed by a healthcare professional.

How to Take

Swallow the tablet whole with a full glass of water; it may be taken with food or milk to lessen stomach upset. Avoid crushing or chewing the tablet, as this can increase local irritation in the esophagus.

Missed Dose

If a dose is missed, take it as soon as you remember unless the next scheduled dose is within a few hours. In that case, skip the missed tablet and resume your regular schedule-do not double-dose.

Overdose

Symptoms of piroxicam overdose include nausea, vomiting, abdominal pain and dizziness. Seek urgent medical attention or call emergency services if you suspect an overdose.

Special Populations

• Elderly: start with the lower 10 mg dose and monitor renal function.
• Renal or hepatic impairment: use only under close supervision; dose reduction may be required.
• Pregnancy & breastfeeding: contraindicated; alternative analgesics should be chosen.
• Children: not approved for paediatric use.

Lifestyle & Diet

• Avoid grapefruit and large amounts of alcohol, as they can increase the risk of gastrointestinal bleeding.
• Maintain adequate hydration, especially if you are active or live in a hot climate.
• If you have a history of ulcer disease, discuss gastro-protective strategies with your clinician.

Safety Precautions

• Gastro-intestinal risk: NSAIDs can cause ulcers, bleeding or perforation; use with food and report any stomach pain promptly.
• Cardiovascular caution: patients with uncontrolled hypertension or heart disease should use Feldene only after risk-benefit assessment.
• Renal monitoring: regular kidney function tests are advised for long-term users.
• Allergy alert: discontinue immediately if you develop rash, itching or swelling.

Drug Interactions

Possible Adverse Effects

Common Side Effects

• Stomach discomfort or dyspepsia
• Nausea or mild vomiting
• Headache

Less Common Side Effects

• Dizziness or light-headedness
• Skin rash or mild itching
• Mild oedema (swelling)

Serious Side Effects

• Gastro-intestinal bleeding or ulcer - seek immediate medical care if you notice black stools or vomiting blood.
• Kidney impairment - watch for reduced urine output or swelling in the ankles.
• Cardiovascular events such as Heart Attack or stroke - call emergency services if you experience chest pain or sudden shortness of breath.

Contraindications

• Known hypersensitivity to piroxicam or any NSAID.
• Active or recent (within 30 days) peptic ulcer disease.
• Severe Heart Failure (class III/IV) or uncontrolled hypertension.
• End-stage renal disease or severe hepatic impairment.
• Pregnancy (especially third trimester) or breastfeeding.

Storage Instructions

• Keep tablets in a tightly closed container at 15 °C to 30 °C (59 °F-86 °F).
• Protect from light, moisture and heat.
• Keep out of reach of children and pets.

Alternative Treatments

Frequently Asked Questions

Can I take Feldene with alcohol?

No, combining alcohol with Feldene increases the risk of stomach bleeding. If you choose to drink, limit intake and monitor for any abdominal pain.

How quickly does Feldene start working?

Pain relief usually begins within 2-4 hours of the first dose. Full anti-inflammatory effects may take several days of consistent use.

Is it safe to take Feldene on an empty stomach?

It is better to take Feldene with food or milk to minimise stomach irritation. If you must take it fasted, monitor for nausea and consider a snack.

Can I use Feldene for chronic back pain?

Yes, Feldene is indicated for chronic musculoskeletal pain, including back pain, when inflammation is a component. Long-term therapy should be reviewed regularly by a healthcare professional.

Does Feldene affect my blood pressure?

NSAIDs can cause a modest rise in blood pressure, especially in salt-sensitive individuals. Check your BP regularly if you have hypertension.

What should I do if I develop a rash while taking Feldene?

Stop the medication immediately and seek medical advice. Rash may signal an allergic reaction that requires prompt assessment.

Can I switch between the 10 mg and 20 mg tablets?

Both strengths are interchangeable, but any change should follow a clinician’s guidance. Do not self-adjust the dose without professional input.

Is long-term use of Feldene safe?

Long-term therapy is possible but requires periodic monitoring of kidney, liver and gastrointestinal health. Discuss the risk-benefit balance with your clinician every few months.

Glossary

• COX (Cyclo-oxygenase): Enzyme that produces prostaglandins, which mediate pain and inflammation.
• Prostaglandins: Chemical messengers that increase blood flow and swelling at injury sites.
• Half-life: Time required for the blood concentration of a drug to decrease by 50 %.
• NSAID: Class of drugs that reduce inflammation, pain and fever by inhibiting COX enzymes.
• Bioequivalence: When a generic product shows the same rate and extent of absorption as the brand-name drug.

Disclaimer

The information provided here is for general educational purposes only and does not replace professional medical advice. Off-label use should only be considered after consulting a qualified healthcare provider. Readers are responsible for verifying the suitability of any medication for their personal health circumstances. Our online pharmacy service offers convenient access to approved medicines, but final decisions about treatment remain with the patient and their clinician.