Buy Glucophage Online

Glucophage (Metformin) Buyer and Patient Handbook in South Africa

Glucophage (Metformin) is an oral antidiabetic pill belonging to the big-uanide class, used primarily to control blood glucose in adults with type 2 diabetes. It works by lowering hepatic glucose production and improving insulin sensitivity. The product is approved by the South African Health Products Regulatory Authority (SAHPRA) and is available in 500 mg, mg and 100 mg tablets.

Who Should Use Glucophage?

• Adults diagnosed with type 2 diabetes mellitus
• Individuals with impaired fasting glucose where lifestyle changes alone are insufficient
• Patients who require an oral agent before considering insulin therapy
• Those seeking a cost-effective, well-studied glucose-lowering option

How Does It Work?

Glucophage reduces the amount of glucose released by the liver and increases the uptake of glucose by muscle cells, similar to turning down a faucet while opening a larger drain. This dual action helps keep blood sugar levels within target ranges during meals and between them. It has a low risk of causing low blood sugar when used alone, but combining it with certain other drugs can raise that risk.

Why Choose Glucophage?

• Proven efficacy: Over 60 years of clinical experience worldwide.
• Cost-effective: Generic formulation offers substantial savings compared with many brand-only options.
• Weight-neutral or modest loss: Unlike some antidiabetic agents, it does not typically cause weight gain.

Off-label uses, such as for Polycystic Ovary Syndrome, should only be considered after professional consultation.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• Start with 500 mg once daily with the evening meal.
• Titrate up to 850 mg twice daily or 100 mg twice daily as needed, based on glycaemic response.

How to Take

• Swallow the tablet whole with a full glass of water.
• Take with food to minimise gastrointestinal upset.

Missed Dose

• If you remember within 12 hours, take it with the next meal.
• Skip it if it is closer to the time of the next scheduled dose.

Overdose

• Seek emergency care immediately.
• Symptoms may include nausea, abdominal Pain and rapid breathing.

Special Populations

• Elderly: Start at 500 mg once daily; monitor renal function closely.
• Renal impairment: Avoid if eGFR < 30 mL/min/1.73 m²; dose-adjust if eGFR 30-45 mL/min/1.73 m².
• Pregnancy & lactation: Generally considered safe, but discuss with a healthcare professional.

Lifestyle & Diet

• Avoid excessive alcohol consumption, which can increase the risk of lactic acidosis.
• No major food interactions, but a balanced diet high in fibre supports optimal glucose control.

Precautions and Warnings

• Renal function must be assessed before initiation and periodically thereafter.
• Contraindicated in patients with known hypersensitivity to metformin or any big-uanide.
• Use with caution in conditions predisposing to hypoxia (e.g., Heart Failure, COPD).

Drug Interactions

Potential Side Effects

Common Side Effects

• Nausea, vomiting, diarrhoea
• Metallic taste
• Mild abdominal discomfort

Less Common Side Effects

• Vitamin B12 deficiency (monitor annually)
• Skin rash or itching

Serious Side Effects

• Lactic acidosis (rare but life-threatening) - seek urgent medical care if you experience severe Fatigue, rapid breathing, or abdominal pain.

Who Should Avoid This Medication?

• Patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²)
• History of lactic acidosis
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis
• Known hypersensitivity to metformin

Storage Instructions

• Keep tablets in the original container, tightly closed.
• Store at controlled room temperature (15-30 °C).
• Protect from moisture and direct sunlight.
• Keep out of reach of children.

Glucophage Alternatives

Frequently Asked Questions

How quickly will Glucophage lower my blood sugar?

Glucose reduction is usually noticeable within 1-2 weeks, with maximal effect after 4-6 weeks of consistent use.

Can I take Glucophage if I drink coffee?

Yes, moderate coffee intake does not affect its action, but avoid excessive caffeine which may increase stomach upset.

Will Glucophage cause me to gain weight?

No, it is generally weight-neutral and may even contribute to modest weight loss in some patients.

Is it safe to exercise while on Glucophage?

Regular exercise is encouraged; just ensure you stay well-hydrated and monitor blood sugar before and after intense activity.

What should I do if I develop persistent diarrhoea?

Report the symptom to a healthcare professional; they may recommend a dose reduction or an extended-release formulation.

Can I use Glucophage during a fast, such as Ramadan?

It can be taken with the pre-dawn and sunset meals; consult a professional to adjust timing if needed.

Does Glucophage interact with herbal supplements?

St. John’s wort may lower metformin levels; discuss any supplements with a healthcare provider.

My blood sugar is still high after a month - what next?

Dose escalation, addition of a second oral agent, or a review of diet and lifestyle may be required; seek professional advice.

Glossary

• Big-uanide: A class of oral antidiabetic drugs that decrease liver glucose production.
• eGFR: Estimated glomerular filtration rate, a measure of kidney function.
• Lactic acidosis: A rare but serious condition where lactic acid builds up in the bloodstream.

Disclaimer

This handbook provides general information about Glucophage (Metformin) and is not a substitute for professional medical advice. Off-label uses should be discussed with a qualified healthcare provider. Readers are responsible for verifying the suitability of any medication for their personal health circumstances. Our service offers educational content and does not dispense medication. Always consult a doctor or pharmacist before starting, stopping, or changing any medication.