Herpes Simplex is an infection caused by herpes viruses 1 or 2 -- which primarily affects the mouth or genital area. People with weakened immune systems are at higher risk for more severe disease. Below you may find medications used to treat or help with Herpes Simplex, Mucocutaneous/Immunocompromised Host. More about Herpes Simplex, Mucocutaneous/Immunocompromised Host