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Phenergan (Promethazine) Buyer and Patient Handbook in South Africa

What is Phenergan?

Phenergan is a antihistamine belonging to the phenothiazine class, used primarily to relieve Allergic Reactions, nausea, and motion-sickness. It is approved by the South African Health Products Regulatory Authority (SAHPRA) and is available in tablet form. The medication works by blocking histamine receptors, which reduces itching, swelling, and the urge to vomit.

Who Should Use Phenergan?

• Adults experiencing moderate to severe allergic symptoms (e.g., hives, itching, swelling)
• Individuals with nausea or motion-sickness when other remedies are ineffective
• Patients who need a short-term sedative effect for procedures or Anxiety (under professional guidance)
• Those without a history of severe heart rhythm disorders or uncontrolled Glaucoma

How Does It Work?

Phenergan blocks H1 histamine receptors in the brain and peripheral tissues, preventing histamine from triggering allergy symptoms. Think of histamine as a messenger that tells blood vessels to leak fluid; Phenergan shuts off that message, keeping vessels tight and reducing swelling. In addition, it dampens the brain’s “vomiting centre,” which explains its anti-nausea effect. Because it also influences dopamine pathways, it can cause mild Sedation, so avoid operating heavy machinery until you know how it affects you.

Why Choose Phenergan?

• Value: As a generic antihistamine, Phenergan offers a cost-effective alternative to newer, brand-only agents without sacrificing efficacy.
• Versatility: It treats both allergic reactions and nausea, reducing the need for multiple medications.
• Proven safety: Decades of clinical use provide a robust safety profile when taken as directed.

Off-label uses (e.g., for Insomnia) should only be considered after consulting a qualified health professional.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• 10 mg tablet: 1-2 tablets every 4-6 hours, not exceeding 40 mg per day.
• 25 mg tablet: 1 tablet every 6-8 hours, not exceeding 75 mg per day.

How to Take

• Swallow the tablet whole with a full glass of water.
• Take with food if you experience stomach upset; otherwise, it may be taken on an empty stomach.

Missed Dose

• If you remember within 2 hours, take the missed dose.
• Skip it if it is closer to the next scheduled dose to avoid double-dosing.

Overdose

• Seek urgent medical attention if more than the maximum daily dose is taken.
• Symptoms may include extreme Drowsiness, rapid heart rate, or Seizures.

Special Populations

• Elderly: Start with the lower 10 mg dose; monitor for excessive sedation.
• Children: Not recommended under 12 years without specialist advice.
• Liver or kidney impairment: Use the lowest effective dose and space doses further apart.

Lifestyle & Diet

• Avoid alcohol or strong sedatives, as they can amplify drowsiness.
• Grapefruit juice may increase blood levels of Phenergan; limit consumption.
• Stay hydrated, especially if using the medication for motion-sickness during travel.

Precautions and Warnings

• Do not use if you have a known hypersensitivity to phenothiazines.
• Caution in patients with Asthma, as high doses can occasionally worsen bronchospasm.
• Avoid prolonged use without medical supervision, as tolerance to the sedative effect may develop.
• Inform your pharmacist of any existing heart rhythm disorders or glaucoma.

Drug Interactions

Potential Side Effects

Common Side Effects

• Drowsiness
• Dry mouth
• Dizziness
• Blurred vision

Less Common Side Effects

• Constipation
• Urinary retention
• Weight gain

Serious Side Effects

• Rapid or irregular heartbeat (Arrhythmia) - seek medical help
• Severe allergic reaction (rash, swelling, breathing difficulty) - seek emergency care
• Signs of extrapyramidal movement disorders (tremor, muscle rigidity) - consult a healthcare professional

Who Should Avoid This Medication?

• Patients with known hypersensitivity to promethazine or other phenothiazines
• Individuals with a history of severe cardiac arrhythmia or prolonged QT interval
• Those with uncontrolled narrow-angle glaucoma
• Pregnant or breastfeeding women unless clearly advised by a clinician

Storage Instructions

• Keep tablets in a tightly closed container at room temperature (15-30 °C).
• Protect from moisture, heat, and direct sunlight.
• Store out of reach of children and pets.

Phenergan Alternatives

Frequently Asked Questions

How quickly does Phenergan start working?

Effect usually begins within 30 minutes, with peak relief at 2-3 hours.

Can I drink coffee while taking Phenergan?

Moderate coffee is acceptable, but avoid excessive caffeine as it may counteract the sedative effect.

Is it safe to drive after a dose?

Do not drive or operate heavy machinery until you know how Phenergan affects you; most people feel drowsy for several hours.

What should I do if I experience severe dizziness?

Sit or lie down immediately, hydrate, and contact a healthcare provider if the sensation persists.

Can I use Phenergan for chronic allergy management?

It is intended for short-term relief; for long-term control, discuss alternative antihistamines with a clinician.

Does Phenergan interact with over-the-counter cold medicines?

Certain decongestants may increase sedation; check the label and consult a pharmacist before combining.

How long can I stay on Phenergan for nausea?

Usually 2-3 days; prolonged use should be reviewed by a health professional.

Is Phenergan available in a liquid form for children?

In South Africa, only tablet formulations are marketed; liquid preparations are not commercially available.

What should I avoid while taking Phenergan?

Alcohol, other sedatives, and grapefruit juice are best avoided to reduce side-effect risk.

How do I know if the medication is working?

Reduction in itching, swelling, or nausea within the first few hours indicates efficacy; if symptoms persist, seek advice.

Glossary

• Histamine receptor (H1): A protein on cells that mediates allergic responses when bound by histamine.
• Phenothiazine: A chemical family that includes both antipsychotics and antihistamines like promethazine.
• Sedation: A state of calmness or drowsiness induced by a medication.

Disclaimer

The information provided here is for general education purposes only and does not replace professional medical advice. Off-label uses should be discussed with a qualified health practitioner. Our online pharmacy offers convenient access to Phenergan, but you remain responsible for ensuring safe and appropriate use. Always consult a doctor or pharmacist before starting, stopping, or altering any medication regimen.