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Periactin (Cyproheptadine) Buyer and Patient Handbook in South Africa

What is Periactin?

Periactin is a first-generation antihistamine in the allergy-asthma drug class. It is used to relieve symptoms of Allergic Rhinitis, Urticaria and to stimulate appetite in certain conditions. The product is approved by the South African Health Products Regulatory Authority (SAHPRA) and is supplied as a 4 mg oral tablet.

Who Should Use Periactin?

• Adults with seasonal or perennial allergic rhinitis
• Individuals experiencing chronic hives (urticaria)
• Patients requiring appetite stimulation (e.g., underweight due to chronic illness)
• Not for use in children under 12 years without specialist advice

How Does It Work?

Cyproheptadine blocks histamine H1 receptors and also has anticholinergic activity, which reduces the body’s allergic response and can increase appetite. Think of it as turning down the “allergy alarm” while also “turning up” hunger signals. The medication has a mild sedating effect, so avoid operating heavy machinery or driving until you know how you react.

Why Choose Periactin?

• Generic advantage: Identical therapeutic effect to brand-name products at a lower cost.
• Established safety record: Decades of use worldwide.
• Off-label uses (e.g., Migraine prophylaxis) should only be considered after consulting a healthcare professional.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• Adults: 4 mg once daily, preferably with food.

How to Take

1. Swallow the tablet whole with a full glass of water.
2. Take it at the same time each day to maintain steady blood levels.

Missed Dose

• If you remember within 6 hours, take it; otherwise skip and resume the regular schedule. Do not double-dose.

Overdose

• Seek emergency medical care immediately if you experience severe Drowsiness, rapid heartbeat, or loss of consciousness.

Special Populations

• Elderly: Start at half the usual dose; monitor for excessive Sedation.
• Liver impairment: Reduce dose by 50 % and monitor liver function tests.
• Pregnancy & breastfeeding: Use only if the benefit outweighs the risk; discuss with a healthcare professional.

Lifestyle & Diet

• Avoid grapefruit juice- it can increase blood levels.
• Limit alcohol, as it may intensify drowsiness.
• Stay hydrated and maintain a balanced diet.

Precautions and Warnings

• May cause drowsiness; avoid driving or dangerous tasks until you know how the drug affects you.
• Use caution if you have Glaucoma, urinary retention, or a history of Asthma attacks.
• Inform any treating clinician that you are taking Periactin.

Drug Interactions

Potential Side Effects

Common Side Effects

• Drowsiness
• Dry mouth
• Weight gain

Less Common Side Effects

• Dizziness
• Nausea
• Blurred vision

Serious Side Effects

• Rapid heartbeat or palpitations - call a doctor
• Severe allergic reaction (rash, swelling) - seek emergency care

Who Should Avoid This Medication?

• Individuals with known hypersensitivity to cyproheptadine or any component of the tablet.
• Patients with severe liver disease without dose adjustment.
• Anyone taking monoamine oxidase inhibitors (MAOIs).

Storage Instructions

• Store below 25 °C (77 °F) in a dry place.
• Keep the bottle tightly closed and out of reach of children.
• Dispose of unused tablets according to local pharmacy guidelines.

Periactin Alternatives

Frequently Asked Questions

How quickly will I feel relief?

Most people notice reduced itching or runny nose within 30 minutes to 1 hour after the first dose.

Can I drink alcohol while taking Periactin?

Alcohol can enhance drowsiness; it is safest to limit or avoid alcohol while on the medication.

Will Periactin make me gain weight?

Weight gain is a known effect due to appetite stimulation; monitor your diet if this is a concern.

Is it safe to take with my asthma inhaler?

Yes, there is no direct interaction, but always inform the prescriber of all medicines you use.

What should I do if I forget a dose?

Take it as soon as you remember, unless it’s almost time for the next dose-then skip the missed one and continue as scheduled.

Can I use Periactin for migraine relief?

It is sometimes used off-label for migraines, but only under medical supervision.

Is Periactin habit-forming?

It is not classified as addictive, but prolonged use should be monitored by a healthcare professional.

How long can I stay on Periactin?

Duration depends on the condition; many patients use it for a few weeks to months. Re-evaluate with a clinician regularly.

Will it affect my driving?

Yes, the sedative effect may impair driving; avoid operating vehicles until you know how the drug affects you.

Can I take it with other allergy medicines?

Some antihistamines may increase drowsiness; talk to a pharmacist before combining them.

Glossary

• Antihistamine: A drug that blocks the action of histamine, a substance that causes allergy symptoms.
• Anticholinergic: A property that reduces secretions and can cause dry mouth or blurred vision.
• Bioequivalence: When a generic product works the same way as a brand-name version.

Disclaimer

The information provided here is for general educational purposes and is not a substitute for professional medical advice. Off-label use should only be undertaken after consulting a qualified healthcare provider. Our platform supplies the medication; the user remains responsible for safe use and for following local regulations.