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Prometrium (Progesterone) Buyer and Patient Handbook in South Africa

What is Prometrium?

Prometrium is a synthetic progesterone pill used to treat hormonal deficiencies in women. It belongs to the class of progestogens and is indicated for luteal-phase support, hormone-replacement therapy, and the management of irregular menstrual cycles. The product is approved by the South African Health Products Regulatory Authority (SAHPRA) and conforms to international quality standards. It is available as oral tablets in 100 mg and 200 mg strengths.

Who Should Use Prometrium?

• Women with confirmed progesterone deficiency (e.g., after ovulation disorders).
• Patients undergoing assisted reproductive technologies who need luteal support.
• Women requiring hormone-replacement therapy during menopause.
• Individuals using progesterone for secondary amenorrhoea under medical supervision.

How Does It Work?

Prometrium mimics the natural hormone progesterone, binding to progesterone receptors in the uterus, breast, and brain. This stabilises the uterine lining, prepares it for implantation, and reduces the risk of menstrual bleeding irregularities. Think of progesterone as a “gatekeeper” that signals the body to maintain a suitable environment for a potential pregnancy. The drug has a low potential for abuse and is not associated with dependence.

Why Choose Prometrium?

• Consistent dosage: Tablet strength is precisely calibrated, ensuring predictable hormone levels.
• High bioavailability: Micronised formulation improves absorption compared with some compounded options.
• Brand reputation: Produced by a multinational manufacturer with a long history of quality control.
• Generic alternative: Identical progesterone tablets are available at a lower cost; both are bio-equivalent.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• 100 mg tablet: typically taken once daily.
• 200 mg tablet: may be prescribed for higher hormonal needs, also once daily.

How to Take

1. Swallow the tablet whole with a full glass of water.
2. Take it at the same time each day to maintain steady hormone levels.
3. It can be taken with or without food; however, a light meal may reduce occasional stomach upset.

Missed Dose

• If you remember the missed dose within 12 hours, take it immediately.
• If more than 12 hours have passed, skip the missed dose and resume your regular schedule.
• Do not double-dose.

Overdose

• Symptoms may include dizziness, nausea, or severe headache.
• Seek immediate medical attention or contact the local poison information centre (e.g., National Poisons Information Service - 080 111 111).

Special Populations

• Elderly: No dose adjustment is required, but monitor for increased sensitivity.
• Pregnancy: Only use when clearly indicated by a specialist.
• Liver impairment: No specific dose change, but watch for prolonged drug clearance.
• Children: Not indicated; progesterone therapy in minors should be managed by a paediatric specialist.

Lifestyle & Diet

• Avoid grapefruit or grapefruit juice within 2 hours of taking the tablet, as it can increase blood levels.
• Moderate caffeine intake; excessive caffeine may exacerbate breast tenderness.
• Maintain a balanced diet rich in calcium and vitamin D to support bone health during Hormone Therapy.

Precautions and Warnings

• Use only under the guidance of a qualified health professional.
• Do not start Prometrium if you are pregnant, have unexplained vaginal bleeding, or have a history of thromboembolic disorders.
• Notify your clinician of any history of breast cancer, liver disease, or severe depression.
• Regular monitoring of hormone levels and uterine health is advised during long-term therapy.

Drug Interactions

Potential Side Effects

Common Side Effects

• Mild nausea
• Breast tenderness
• Headache
• Drowsiness

Less Common Side Effects

• Mood swings
• Bloating or abdominal discomfort
• Spotting between periods

Serious Side Effects

• Severe allergic reaction (rash, swelling, breathing difficulty) - seek emergency care
• Signs of blood clots (leg Pain, swelling, sudden breathlessness) - call emergency services
• Unusual vaginal bleeding or discharge - consult a healthcare professional promptly

Who Should Avoid This Medication?

• Individuals with known allergy to progesterone or any tablet excipients.
• Women with active thromboembolic disease (e.g., deep-vein thrombosis).
• Patients with uncontrolled hypertension or recent stroke.
• Anyone who is pregnant without a clear medical indication for progesterone support.

Storage Instructions

• Keep tablets in the original container, tightly closed.
• Store at 20-25 °C (68-77 °F), away from excess heat and moisture.
• Do not refrigerate or freeze.
• Keep out of reach of children and pets.

Prometrium Alternatives

Frequently Asked Questions

How long does it take for Prometrium to show an effect?

Most women notice a stabilisation of their menstrual cycle within 2-3 weeks of consistent use.

Can I take Prometrium while drinking alcohol?

Moderate alcohol consumption does not interfere with hormone absorption, but excessive intake may increase side-effects such as dizziness.

Is it safe to use Prometrium during breastfeeding?

Progesterone passes into breast milk in low amounts; most clinicians consider it compatible with breastfeeding when medically indicated.

What should I do if I experience severe headache?

A persistent or severe headache may signal elevated hormone levels; contact your healthcare provider for assessment.

Can I switch from a generic progesterone to Prometrium?

Yes, both contain the same active ingredient; discuss any dose adjustments with your clinician.

Does Prometrium interact with hormonal contraceptives?

Progesterone does not reduce the effectiveness of combined oral contraceptives, but concurrent use should be reviewed by a professional.

Will Prometrium cause weight gain?

Some users report modest fluid retention, but significant weight gain is uncommon.

How should I store the tablets when traveling?

Carry them in a cool, dry pouch within your hand luggage; avoid exposure to high temperatures in car trunks or checked baggage.

Glossary

• Progestogen - A class of hormones that mimic natural progesterone, essential for regulating the menstrual cycle and supporting early pregnancy.
• Bioavailability - The proportion of a drug that reaches systemic circulation and is able to exert its effect.
• Luteal-phase support - Hormonal supplementation after ovulation to maintain the uterine lining for embryo implantation.

Disclaimer

The information in this handbook is for educational purposes only and does not replace professional medical advice. Off-label uses should be discussed with a qualified health practitioner. Our service provides general drug information; it is not a substitute for personalized medical consultation. Always read the product label and consult a doctor or pharmacist before starting any new medication.