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Kessar (Tamoxifen) Buyer and Patient Handbook in South Africa

What is Kessar?

Kessar is a selective estrogen receptor modulator (SERM) sold as tablets and used primarily to treat and prevent hormone-responsive Breast Cancer in women. It belongs to the breast-cancer therapy class and is approved by the South African Health Products Regulatory Authority (SAHPRA) and the U.S. FDA. Kessar is available in 10 mg and 20 mg film-coated tablets.

Who Should Use Kessar?

• Women diagnosed with estrogen-receptor-positive (ER+) breast Cancer
• Women at high risk of developing breast cancer (e.g., strong family history)
• Post-menopausal women requiring hormonal cancer prevention
• Patients under the care of an oncology specialist who have been deemed suitable for SERM therapy

How Does It Work?

Kessar binds to estrogen receptors in breast tissue, blocking estrogen’s ability to stimulate cancer cell growth. Think of it as a key that fits into the lock but turns it the wrong way, preventing the door (cancer cells) from being opened. While it blocks estrogen in the breast, it can act like estrogen in bone and liver, helping maintain bone density and liver function. Because it interferes with hormone pathways, misuse or unsupervised high-dose use can cause serious health risks.

Why Choose Kessar?

• Proven efficacy: Clinical trials have shown Kessar reduces breast-cancer recurrence by up to 50 % in eligible women.
• Convenient dosing: Once-daily oral tablets eliminate the need for injections.
• Brand consistency: Manufactured under strict Good Manufacturing Practice (GMP) standards; generic tamoxifen tablets are available at lower cost, offering the same therapeutic effect.
• Off-label uses (e.g., infertility, gynecomastia) should only be considered after specialist consultation.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• 10 mg tablet: Typically 20 mg daily (two 10 mg tablets) for preventive therapy.
• 20 mg tablet: One tablet daily for treatment of established breast cancer.

How to Take

1. Swallow the tablet whole with a full glass of water.
2. Take at the same time each day to maintain steady blood levels.
3. Food does not affect absorption; you may take it with meals or on an empty stomach.

Missed Dose

If you miss a dose and it is within 12 hours, take it as soon as you remember. If more than 12 hours have passed, skip the missed dose and resume your regular schedule. Do not double-dose.

Overdose

Symptoms may include nausea, vomiting, dizziness, or severe abdominal Pain. Seek emergency medical care immediately; inform the team that tamoxifen was taken in excess.

Special Populations

• Elderly: No dosage reduction needed, but monitor liver function closely.
• Children & Adolescents: Not recommended except under strict oncology supervision.
• Renal or hepatic impairment: No routine dose adjustment, but regular liver-function tests are advised.

Lifestyle & Diet

• Alcohol: Moderate consumption is acceptable; excessive intake may increase liver strain.
• Grapefruit & grapefruit juice: May raise tamoxifen levels; avoid large quantities.
• Smoking: Does not affect drug levels but worsens overall cancer risk-cessation is encouraged.

Precautions and Warnings

• Do not use if you are pregnant or plan to become pregnant; tamoxifen can cause fetal harm.
• Use effective contraception during treatment and for two months after stopping.
• Regular breast examinations and imaging are recommended to monitor treatment response.
• Watch for signs of blood clots (leg pain, swelling, shortness of breath) and report immediately.

Drug Interactions

Potential Side Effects

Common Side Effects

• Hot Flashes
• Nausea or mild stomach upset
• Vaginal discharge or dryness
• Mild Fatigue

Less Common Side Effects

• Mood swings or Depression
• Headache
• Joint or muscle pain

Serious Side Effects (seek medical help)

• Deep-vein thrombosis or pulmonary embolism
• Severe liver injury (jaundice, dark urine)
• Unexplained weight loss or persistent Cough
• Vision changes or eye pain (possible retinal issues)

Who Should Avoid This Medication?

• Pregnant or breastfeeding women
• Women with a known hypersensitivity to tamoxifen or any tablet excipients
• Patients with a history of recurrent thromboembolic disease unless benefits outweigh risks

Storage Instructions

• Keep tablets in the original container, tightly closed.
• Store at 15 °C - 30 °C (room temperature), away from moisture and direct sunlight.
• Keep out of reach of children and pets.

Kessar Alternatives

Frequently Asked Questions

How long will I need to stay on Kessar?

Most treatment plans last 5 years for breast-cancer therapy; preventive regimens may extend up to 10 years based on doctor assessment.

Can I drink coffee while taking Kessar?

Yes, moderate coffee intake does not affect tamoxifen’s action. Excessive caffeine may increase Anxiety or Insomnia, so monitor your tolerance.

Will Kessar cause weight gain?

Weight changes are not a typical side effect. Some patients experience mild fluid retention, but significant weight gain is uncommon.

Is it safe to take Kessar with over-the-counter pain relievers?

Acetaminophen is generally safe. NSAIDs (ibuprofen, naproxen) can increase the risk of stomach irritation; use with food and consult your clinician if you need regular pain relief.

My periods stopped after starting Kessar-should I be concerned?

Irregular or absent menstrual cycles are a common hormonal effect. Notify your doctor if bleeding stops for more than three months, especially if you are still of reproductive age.

Can I become pregnant while on Kessar?

No. Tamoxifen is teratogenic. Use reliable contraception throughout treatment and for at least 2 months after the final dose.

What should I do if I experience a hot flash at night?

Dress in lightweight, breathable clothing, keep your bedroom cool, and avoid spicy meals before bedtime. If hot flashes are severe, discuss possible management options with your oncologist.

Does Kessar interact with herbal supplements like St John’s wort?

St John’s wort induces CYP enzymes and may lower tamoxifen levels, reducing effectiveness. Avoid it unless your healthcare provider approves.

How often will I need blood tests while on Kessar?

Typically, liver-function tests are performed every 3-6 months; additional monitoring (e.g., lipid profile, coagulation) may be ordered based on individual risk factors.

Glossary

• Selective Estrogen Receptor Modulator (SERM): A drug that blocks estrogen receptors in some tissues (like breast) while mimicking estrogen in others (like bone).
• CYP2D6: A liver enzyme that converts tamoxifen into its most active form; some medications can inhibit this conversion.
• Thromboembolism: Formation of a blood clot that can travel through the bloodstream and block vessels, potentially causing serious complications.

Disclaimer

The information provided here is for general educational purposes and does not replace professional medical advice. Off-label uses should only be considered after discussion with a qualified healthcare provider. Our online pharmacy service offers convenient access to approved medicines, but the ultimate responsibility for safe use rests with the patient and their treating clinician. Always consult your doctor or pharmacist before starting, stopping, or changing any medication.