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Duphaston (Dydrogesterone) Buyer and Patient Handbook in South Africa

What is Duphaston?

Duphaston is a synthetic progestogen tablet used primarily to treat conditions related to Progesterone deficiency, such as menstrual disorders, infertility associated with luteal phase defects, and hormonal support in early pregnancy. It belongs to the class of progestins and is approved by the South African Health Products Regulatory Authority (SAHPRA). The medication is supplied as a 10 mg oral pill.

Who Should Use Duphaston?

• Women with irregular or absent menstrual cycles.
• Patients experiencing luteal phase insufficiency affecting fertility.
• Women requiring progesterone support in assisted reproductive techniques.
• Individuals under hormonal therapy for endometriosis-related Pain (under medical supervision).

How Does It Work?

Dydrogesterone, the active ingredient, mimics natural progesterone by binding to progesterone receptors in the uterus and other target tissues. This stabilises the uterine lining, preparing it for implantation and sustaining early pregnancy. It also reduces the over-growth of the endometrium, helping to regularise bleeding patterns.

Why Choose Duphaston?

• Targeted action: Provides progestogenic activity without significant androgenic or estrogenic effects, which can reduce unwanted side-effects.
• Established safety profile: Widely used in Europe and South Africa for decades with robust clinical data.
• Convenient dosing: Once-daily oral tablet simplifies adherence.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• 10 mg taken once daily, usually in the evening.

How to Take

• Swallow the tablet whole with a full glass of water.
• It can be taken with or without food; consistency helps maintain steady blood levels.

Missed Dose

• If you are less than 12 hours late, take the missed tablet as soon as you remember and then continue with the regular schedule.
• If more than 12 hours have passed, skip the missed dose and resume the next day; do not double-dose.

Overdose

• Seek immediate medical attention if a large amount is ingested.
• Symptoms may include nausea, vomiting, or Abnormal Uterine Bleeding.

Special Populations

• Elderly: No specific dose adjustment, but monitor for thrombotic risk.
• Children: Not indicated.
• Renal or hepatic impairment: No dose change required, but use caution and regular monitoring.

Lifestyle & Diet

• Avoid grapefruit or grapefruit juice, which can alter drug metabolism.
• Moderate alcohol consumption; excessive intake may increase the risk of Uterine Bleeding.
• Maintain a balanced diet rich in vitamins A, C, and E to support hormonal health.

Precautions and Warnings

• Use only under the guidance of a qualified healthcare professional.
• Discontinue if you develop signs of thrombosis (e.g., leg pain, swelling, sudden shortness of breath).
• Inform your provider of any history of breast, uterine, or ovarian Cancer.
• Do not use during known or suspected pregnancy unless specifically prescribed for luteal support.

Drug Interactions

Potential Side Effects

Common Side Effects

• Nausea
• Headache
• Breast tenderness

Less Common Side Effects

• Mood changes (e.g., irritability)
• Slight weight gain
• Mild abdominal cramps

Serious Side Effects

• Unexplained vaginal bleeding
• Signs of blood clots (pain/swelling in legs, chest pain)
• Severe allergic reaction (rash, itching, swelling) - seek urgent medical care

Who Should Avoid This Medication?

• Women with a known hypersensitivity to dydrogesterone or any tablet excipients.
• Patients with active or a history of thromboembolic disease.
• Individuals with uncontrolled hypertension or severe liver disease.

Storage Instructions

• Store in a dry place at 20-25 °C (68-77 °F).
• Keep the bottle tightly closed and protect from light.
• Keep out of reach of children.

Duphaston Alternatives

Frequently Asked Questions

How long should I take Duphaston for menstrual regulation?

Typically 5-10 days each cycle, but the exact duration depends on your clinician’s assessment.

Can I take Duphaston if I am trying to conceive?

Yes, it is often prescribed to support the luteal phase in fertility treatments, but only under medical supervision.

Does Duphaston affect my mood?

Some users report mood fluctuations, though many experience no change; discuss any concerns with your provider.

Is it safe to drink coffee while on Duphaston?

Moderate coffee intake (up to 2 cups daily) is generally safe, but excessive caffeine may exacerbate jitteriness.

Will Duphaston cause weight gain?

Mild weight changes can occur, but significant gain is uncommon.

Can I use Duphaston during breastfeeding?

It passes into breast milk in small amounts; consult a healthcare professional before use.

What should I do if I experience breakthrough bleeding?

Report the bleeding to your provider; they may adjust the dose or investigate other causes.

Are there any herbal supplements that interfere with Duphaston?

St. John’s wort can induce metabolism and reduce effectiveness, so avoid concurrent use unless approved by a clinician.

Glossary

• Progestogen - A class of hormones that mimic the effects of natural progesterone.
• Luteal phase - The post-ovulation phase of the menstrual cycle when progesterone prepares the uterus for possible implantation.
• Thromboembolism - Formation of a blood clot that can travel through the bloodstream and block vessels.

Disclaimer

This handbook provides general information about Duphaston (dydrogesterone) and is not a substitute for professional medical advice. Off-label use should only occur after discussion with a qualified healthcare provider. Our service offers educational content and product details; responsibility for therapeutic decisions rests with the reader and their clinician.