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Cycrin (Medroxyprogesterone) Buyer and Patient Handbook - South Africa

What is Cycrin?

Cycrin is a synthetic progestogen belonging to the Progesterone class, used to treat a range of women's health conditions. It is approved by the South African Health Products Regulatory Authority (SAHPRA) and is available as an oral pill. Common indications include menstrual disorders, hormonal replacement therapy, and prevention of endometrial hyperplasia.

Who Should Use Cycrin?

• Women of reproductive age experiencing irregular menstrual cycles.
• Post-menopausal women needing hormone replacement therapy.
• Patients requiring endometrial protection while on estrogen therapy.
• Individuals prescribed Cycrin by a qualified health professional for approved indications.

How Does It Work?

Cycrin mimics natural progesterone, binding to progesterone receptors in the uterus and other tissues. By activating these receptors, it stabilises the endometrium, preventing over-growth and regulating the menstrual cycle. Think of it as a “traffic controller” that tells the uterine lining when to build and when to shed, keeping the cycle orderly.

Safety note: Medroxyprogesterone has a low potential for abuse, but it is not intended for non-medical use.

Why Choose Cycrin?

• Efficacy: Provides reliable progesterone activity for the approved conditions.
• Convenience: Once-daily oral tablet, easy to incorporate into daily routines.
• Quality: Manufactured under stringent Good Manufacturing Practice (GMP) standards; generic alternatives are bioequivalent and often more affordable.

Off-label use (e.g., for contraception) should only be considered after professional consultation.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• 5 mg tablet - typically prescribed for menstrual regulation.
• 10 mg tablet - often used in hormone replacement therapy. Dosage and frequency are determined by the treating clinician based on the indication and individual response.

How to Take

1. Swallow the tablet whole with a full glass of water.
2. Take it at the same time each day to maintain steady hormone levels.
3. Food does not significantly affect absorption, so it may be taken with or without meals.

Missed Dose

If you remember within 12 hours of the scheduled time, take the missed tablet immediately. If it is later than 12 hours, skip the missed dose and continue with the next scheduled tablet. Do not double-dose.

Overdose

If an overdose is suspected, seek urgent medical attention. Symptoms may include nausea, vomiting, or severe headache. Prompt professional care is essential.

Special Populations

• Elderly: No dose adjustment is routinely required, but monitor for cardiovascular risk factors.
• Children/Adolescents: Not indicated; Cycrin is reserved for adult women.
• Liver or kidney impairment: No specific dosage change, but clinicians may opt for closer monitoring.

Lifestyle & Diet

• Alcohol: Moderate consumption is acceptable; excessive intake may increase liver load.
• Caffeine: No restriction, but maintain usual intake.
• Grapefruit juice: Can interfere with hormone metabolism; avoid large quantities.

Precautions and Warnings

• Do not use if you are pregnant or planning to become pregnant.
• Report any history of blood clots, stroke, or uncontrolled hypertension to your clinician.
• Cycrin may increase the risk of endometrial cancer if used without concurrent estrogen protection in certain women.
• Regular follow-up appointments are recommended to assess therapeutic response and side-effects.

Drug Interactions

Potential Side Effects

Common Side Effects

• Headache
• Nausea or mild abdominal discomfort
• Breast tenderness

Less Common Side Effects

• Mood changes (e.g., irritability)
• Weight gain or fluid retention

Serious Side Effects

• Severe abdominal Pain or vaginal bleeding
• Signs of blood clot (leg swelling, chest pain, shortness of breath)
• Immediate medical attention is required if any of these occur.

Who Should Avoid This Medication?

• Pregnant women or those trying to conceive.
• Women with known hypersensitivity to medroxyprogesterone or any tablet excipients.
• Patients with active deep vein thrombosis, pulmonary embolism, or uncontrolled hypertension.

Storage Instructions

• Keep tablets in the original container, tightly closed.
• Store at room temperature (15-30 °C), away from moisture and direct sunlight.
• Keep out of reach of children and pets.

Cycrin Alternatives

Frequently Asked Questions

How long does it take for Cycrin to regulate my cycle?

Most women notice a regularisation of periods within 1-2 menstrual cycles after consistent use.

Can I take Cycrin while drinking coffee?

Yes, moderate coffee consumption does not interfere with Cycrin’s effectiveness.

Is it safe to consume alcohol while on Cycrin?

Moderate alcohol intake is generally safe, but excessive drinking may increase liver strain and should be avoided.

What should I do if I experience breakthrough bleeding?

Contact your health professional; they may adjust the dose or evaluate for underlying conditions.

Does Cycrin protect against pregnancy?

Cycrin is not a contraceptive. Use an approved Birth Control method if pregnancy prevention is required.

Can I use Cycrin if I have a history of blood clots?

No, contraindicated in patients with a history of thromboembolic events.

How should I store Cycrin during a power outage?

Maintain tablets at room temperature; they are stable for short periods without refrigeration.

Are there any herbal supplements that interact with Cycrin?

St. John’s Wort can induce metabolism and lower hormone levels; avoid concurrent use.

What is the difference between a 5 mg and 10 mg tablet?

The 10 mg tablet delivers a higher hormone dose, typically used for hormone replacement therapy, whereas the 5 mg tablet is suited for menstrual regulation.

Can I switch from a brand product to a generic version?

Yes, generic medroxyprogesterone is bioequivalent and can be substituted under professional guidance.

Glossary

• Progestogen: A synthetic hormone that mimics natural progesterone, regulating the menstrual cycle and supporting pregnancy.
• Endometrial hyperplasia: Thickening of the uterine lining, which can increase Cancer risk if untreated.
• CYP3A4: An enzyme in the liver that metabolises many drugs; inhibitors can raise drug levels.

Disclaimer

The information provided here is for general educational purposes only and does not constitute medical advice. Off-label uses require professional consultation. Readers are responsible for verifying any information before acting on it. Our platform offers online pharmacy services that facilitate the purchase of approved medicines; it does not replace the role of a qualified health professional. Always consult a licensed clinician before starting, stopping, or changing any medication.