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Seroflo Inhaler (Fluticasone Plus Salmeterol) Buyer and Patient Handbook in South Africa

What is Seroflo Inhaler?

Seroflo Inhaler is a fixed-dose combination inhaler containing fluticasone propionate (an inhaled corticosteroid) and salmeterol (a long-acting β2-agonist). It belongs to the controller-type inhaled therapies used for Asthma and chronic obstructive pulmonary disease (COPD). The device delivers the medication as a metered-dose spray, available in two strengths: 25 µg fluticasone + 125 µg salmeterol, and 25 µg fluticasone + 250 µg salmeterol per actuation. It is approved by the South African Health Products Regulatory Authority (SAHPRA) and listed in the WHO Essential Medicines List.

Who Should Use Seroflo Inhaler?

• Adults and adolescents (≥12 years) with persistent asthma not controlled on low-dose inhaled corticosteroid alone.
• Patients with COPD who require both bronchodilation and anti-inflammatory treatment.
• Individuals seeking twice-daily dosing for convenient symptom control.

How Does It Work?

The inhaler supplies fluticasone, which reduces airway inflammation by inhibiting cytokine production, and salmeterol, which relaxes airway smooth muscle for up to 12 hours. Think of fluticasone as a fire-extinguisher that cools the inflamed airways, while salmeterol acts like a steady breeze that keeps the airway open. The combined effect improves breathing and reduces the frequency of exacerbations.

Why Choose Seroflo Inhaler?

• Convenient twice-daily dosing simplifies routine compared with separate inhalers.
• The fixed-dose combination ensures consistent delivery of both drugs, improving adherence.
• Generic alternatives containing the same active ingredients are available for cost-saving options.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• 25 µg fluticasone + 125 µg salmeterol: one inhalation twice daily.
• 25 µg fluticasone + 250 µg salmeterol: one inhalation twice daily. Dose is selected by a qualified healthcare professional based on disease severity### How to Take
  1. Shake the inhaler gently for 5 seconds.
  2. Exhale fully, then place the mouthpiece between your lips.
  3. Press the canister once while inhaling slowly and deeply.
  4. Hold breath for about 10 seconds, then exhale gently.

Missed Dose

If a scheduled dose is missed, take it as soon as you remember unless it is within 1 hour of the next dose. In that case, skip the missed dose and resume the regular schedule. Do not double-dose.

Overdose

Symptoms may include tremor, rapid heart rate, or severe throat irritation. Seek immediate medical attention or call emergency services if you suspect an overdose.

Special Populations

• Elderly: Start at the lower strength; monitor for throat irritation.
• Children <12 years: Not approved for routine use.
• Renal or hepatic impairment: No dosage adjustment needed, but use caution and observe for side effects.

Lifestyle & Diet

• Avoid using the inhaler immediately after vigorous exercise; allow a short pause to improve drug deposition.
• Grapefruit juice may increase systemic exposure to fluticasone; limit large quantities.
• Rinse mouth with water after each use to reduce the risk of oral thrush.

Precautions and Warnings

• Do not use as a rescue inhaler for sudden breathlessness; keep a short-acting bronchodilator handy.
• Long-term use may slightly increase the risk of Pneumonia in COPD patients.
• Monitor for signs of adrenal suppression, especially with high-dose fluticasone.

Drug Interactions

Potential Side Effects

Common Side Effects

• Hoarseness or throat irritation
• Oral candidiasis (thrush)
• Headache

Less Common Side Effects

• Muscle cramps
• Nasal congestion
• Mild tremor

Serious Side Effects

• Severe allergic reaction (rash, swelling, difficulty breathing) - seek emergency care
• Paradoxical bronchospasm - stop inhaler and contact a clinician
• Signs of adrenal insufficiency (Fatigue, nausea) - consult a healthcare professional

Who Should Avoid This Medication?

• Patients with a known hypersensitivity to fluticasone, salmeterol, or any inhaler excipients.
• Individuals who have experienced a severe asthma attack after using a long-acting β2-agonist.
• Patients with untreated cardiac arrhythmias or uncontrolled hypertension.

Storage Instructions

• Keep the inhaler at room temperature (15-30 °C).
• Protect from direct sunlight and moisture.
• Store out of reach of children; ensure the cap is tightly closed when not in use.

Seroflo Inhaler Alternatives

Frequently Asked Questions

How quickly will I notice improvement after starting Seroflo Inhaler?

Most patients experience better symptom control within 1-2 weeks, though full anti-inflammatory benefit may take up to 4 weeks.

Can I use Seroflo Inhaler with my rescue inhaler?

Yes. The rescue (short-acting) inhaler should be kept for sudden breathlessness and used as directed.

Is it safe to use Seroflo Inhaler while pregnant?

Animal studies show no harm, but human data are limited. Discuss risks and benefits with your clinician.

What should I do if I develop oral thrush?

Rinse your mouth with water and spit it out after each dose. If thrush persists, seek medical advice for possible antifungal treatment.

Can I take this inhaler if I have a heart condition?

Use with caution. Salmeterol may increase heart rate; inform your doctor if you have arrhythmias or uncontrolled hypertension.

Does the inhaler contain lactose?

Yes, the propellant carrier includes lactose. Patients with severe lactose intolerance should discuss alternatives with their clinician.

Why is my inhaler making a clicking sound?

The click is a normal part of the metering mechanism and indicates a dose has been released.

Can alcohol affect the action of Seroflo Inhaler?

Moderate alcohol consumption does not interfere with the medication, but excessive intake may worsen breathing problems.

What is the correct way to clean the inhaler mouthpiece?

Wipe the mouthpiece with a clean, dry cloth weekly. Do not wash with water to avoid moisture damage.

How long can I store the inhaler after opening it?

Check the label for the “use-by” date; most inhalers remain effective for 4-6 weeks after first use, provided the dose counter is not exceeded.

Glossary

• Inhaled corticosteroid (ICS): A steroid medication delivered directly to the lungs to reduce inflammation.
• Long-acting β2-agonist (LABA): A bronchodilator that relaxes airway muscles for up to 12 hours.
• Adrenal suppression: Reduced production of natural steroids by the adrenal glands, potentially caused by high-dose corticosteroids.

Disclaimer

The information provided here is for general educational purposes only and does not replace professional medical advice. All medication uses described are based on approved indications; off-label use should be discussed with a qualified healthcare provider. Readers are responsible for verifying suitability and safety for their individual health situation. Our online pharmacy platform offers access to approved medicines; we do not prescribe or dispense without appropriate clinical assessment. Always consult a qualified health professional before initiating or changing any treatment.