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Primary Hypercholesterolaemia

Primary hypercholesterolaemia is an inherited condition in which the body cannot clear low-density lipoprotein (LDL) cholesterol effectively, so levels build up in the blood from a young age.

Nexletol

Bempedoic Acid

180mg

Bempedoic acid tablets for high cholesterol. It lowers LDL cholesterol by blocking an early step in the liver's cholesterol production.

From$1.93/ tabletView

Ezetimibe Tablets

Ezetimibe

10mg

Ezetimibe tablets for high cholesterol. It stops cholesterol being absorbed from food and bile in the intestine.

From$1.62/ tabletView

Key points

  • Physical signs such as swollen Achilles tendons, yellowish patches around the eyes, or a whitish-gray ring at the corneal edge can accompany the condition, though many people show no visible markers.
  • An LDL cholesterol level above 190 mg/dL in adults, often alongside a family history of early heart disease, is a principal indicator of the inherited form.
  • Diet and exercise alone are usually insufficient to bring cholesterol to a safe range in inherited cases, so cholesterol-lowering medicines are typically needed.

Medicines listed for Primary Hypercholesterolaemia

The two products listed for this condition contain bempedoic acid and ezetimibe, both in tablet form. Bempedoic acid reduces the liver’s own cholesterol production, while ezetimibe limits the amount of cholesterol absorbed from the intestine. Both target different steps in the cholesterol pathway and serve as cholesterol-lowering options for inherited hypercholesterolaemia.

Further reading