Isotretinoin
Three isotretinoin capsule brands line this shelf: Accutane, Accufine and Isotroin, all used to treat Severe Recalcitrant Nodular Acne that has not cleared with antibiotics.
Key points
- Isotretinoin belongs to the retinoid class and attacks all four causes of acne: bacteria, clogged pores, excess oil and inflammation.
- It carries a boxed warning for severe birth defects and pregnancy loss; it must not be taken by anyone who is or may become pregnant.
- Accutane is the original brand by Roche; Accufine and Isotroin are Indian generic versions of the same molecule.
How does isotretinoin work?
Isotretinoin shrinks the oil-producing glands in your skin and cuts the amount of oil they release. At the doses used for acne, it also slows the buildup of dead skin cells that clog pores.
The exact mechanism is unclear, but the result is straightforward: less oil, fewer clogged pores and a less hospitable environment for acne-causing bacteria. About 85% of patients see permanent clearing after one course.
Brands and forms in this catalogue
All three products in this Skin Care listing are oral capsules containing isotretinoin. What separates them is the brand behind the molecule and the strength range each one covers.
Accutane is the original brand, first marketed by Roche, and comes in five strengths from 5 mg up to 40 mg. Accufine, from Healing Pharma in India, is a generic version available at 30 mg. Isotroin, manufactured by Cipla, covers 10 mg, 20 mg and 30 mg. Different companies make the same molecule under their own names, which is why several brands exist for one ingredient. A South African reader may recognise Accutane from older packs or international references, while Accufine and Isotroin are Indian generic lines carrying the same active ingredient.