Buspirone
Buspirone, sold as Buspar, is an anxiolytic used for Generalised Anxiety Disorder. The single product on this shelf comes in 5 mg and 10 mg tablets.
Key points
- Buspirone is an anxiolytic with a distinct serotonergic mechanism, acting on serotonin 5-HT1A receptors.
- Its effect develops over time; it is not a sedative and does not cause dependence.
- The medicine-specific cautions include dizziness, nausea and interactions with monoamine oxidase inhibitors or strong CYP3A4 modifiers.
How does Buspirone work?
Buspirone binds to serotonin 5-HT1A receptors in the brain, a mechanism separate from the sedative anti-anxiety drugs that work through a different receptor system. The result is a gradual easing of anxious tension over time, without the drowsiness or dependence risk that characterises benzodiazepines. Buspar, the original brand, is listed under Mental Health in 5 mg and 10 mg strengths.