Ciclosporin Capsules
Rheumatoid Arthritis, Psoriasis
50mg · 100mg
Ciclosporin capsules for rheumatoid arthritis and psoriasis. It suppresses T-lymphocyte activity by blocking a specific cell-signalling pathway.
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Ciclosporin
One ciclosporin product sits on this shelf: Ciclosporin Capsules (Neoral) in 50 mg and 100 mg. It is a calcineurin-inhibitor immunosuppressant used to prevent organ rejection and to calm severe Rheumatoid Arthritis and Psoriasis.
Key points
- Ciclosporin can cause nephrotoxicity and systemic hypertension at recommended doses, with risk rising with dose and duration; psoriasis patients previously treated with PUVA face an added risk of skin malignancy.
- Regular serum creatinine monitoring is required during treatment to catch kidney changes early.
- Ciclosporin dampens the immune system, which raises the risk of bacterial, fungal and viral infections, often involving opportunistic pathogens.
How does Ciclosporin work?
Ciclosporin (also called ciclosporin A) blocks a specific cell-signalling pathway inside T cells, the white blood cells that coordinate immune attacks. It stops these cells from releasing interleukin 2, a chemical messenger that tells other immune cells to multiply and launch an inflammatory response.
The practical effect is a quieter immune system. In transplant patients, that means the body is less likely to reject a new kidney, liver or heart. In autoimmune conditions like rheumatoid arthritis and severe psoriasis, it reduces the immune system’s attack on the body’s own tissue. This is why ciclosporin appears in Autoimmune Support alongside other immune-modulating medicines.