Tenofovir Alafenamide
On this shelf, tenofovir alafenamide appears in one product: Biktarvy, a single tablet combining 50 mg tenofovir alafenamide, 200 mg bictegravir and 25 mg emtricitabine for HIV-1 infection.
Key points
- Tenofovir alafenamide is a nucleoside reverse transcriptase inhibitor (NRTI) that works by reducing the amount of virus in the blood.
- Renal impairment, including acute kidney failure and Fanconi syndrome, has been reported with tenofovir alafenamide-containing products, so kidney function is monitored during treatment.
How does tenofovir alafenamide work?
Tenofovir alafenamide is a prodrug: the body converts it into tenofovir, the active form that interferes with reverse transcriptase, the enzyme HIV uses to copy its genetic material. Blocking that step slows the virus from making new copies of itself. In Biktarvy, tenofovir alafenamide works alongside bictegravir and emtricitabine, each targeting a different stage of the HIV life cycle, as part of HIV Management.