Exforge
Amlodipine and valsartan tablets for high blood pressure. Two medicines in one pill, each lowering pressure differently.
All strengths and pack prices
| Strength | Pack | Price | Per unit |
|---|---|---|---|
| 5mg + 80mg | 20 tablets | $73.00 | $3.65 |
| 5mg + 80mg | 60 tablets | $99.00 | $1.65 |
| 5mg + 80mg | 120 tablets | $136.00 | $1.13 |
- Category
- Heart & Blood Pressure
- Active ingredients
- Amlodipine · Valsartan
- Route
- Oral use
- Form
- Tablet; Film-coated tablet
- Strengths
- 5mg + 80mg
Exforge is the reference name. You receive a generic with the same active ingredient and strength.
No prescription needed: we place your order for Exforge on your behalf.
- Condition
- Hypertension
- Alternative names
- Dafiro
- Therapeutic class
- Angiotensin II antagonists and calcium channel blockers
- Pharmacological class
- Dihydropyridine calcium channel blocker; Angiotensin II receptor blocker
- Dosage forms
- Tablet; Film-coated tablet
- Administration route
- Oral use
- Originator
- Novartis
- Duration
- 24 hours
- Storage instructions
- Store below 30°C. Store in the original package to protect from moisture.
Contraindications
hypersensitivity to amlodipine, valsartan, dihydropyridine derivatives or any excipient; severe hepatic impairment; biliary cirrhosis; cholestasis; concomitant use with aliskiren in patients with diabetes mellitus or renal impairment; second and third trimesters of pregnancy; severe hypotension; shock including cardiogenic shock; obstruction of the outflow tract of the left ventricle; haemodynamically unstable heart failure after acute myocardial infarction
Precautions and warnings
sodium and volume depletion should be corrected before starting treatment; risk of hypotension in volume-depleted patients; hyperkalaemia monitoring; renal artery stenosis; renal impairment with monitoring of potassium and creatinine; mild to moderate hepatic impairment with dose adjustment; risk of increased angina or myocardial infarction on initiation or dose increase of calcium channel blocker; heart failure; aortic or mitral valve stenosis; elderly patients requiring caution with dose increases; angiotensin II receptor antagonists should not be initiated during pregnancy
Minor side effects
peripheral oedema; headache; dizziness; fatigue; nasopharyngitis; upper respiratory tract infection; flushing; asthenia; nausea; abdominal pain; dyspepsia
Moderate side effects
hypotension; orthostatic hypotension; syncope; hyperkalaemia; renal impairment; angina pectoris; myocardial infarction; arrhythmia; hypersensitivity reactions; angioedema; hepatitis; pancreatitis; thrombocytopenia
Serious side effects
angioedema, requires immediate medical attention; myocardial infarction, requires immediate medical attention; severe hypotension, requires immediate medical attention; acute renal failure, requires immediate medical attention; severe hyperkalaemia, requires immediate medical attention; hepatitis, requires immediate medical attention
Patient summary
Amlodipine and valsartan tablets for high blood pressure. Two medicines in one pill, each lowering pressure differently.
Mechanism of action
Exforge contains two medicines that help control high blood pressure. Amlodipine is a calcium channel blocker that works by relaxing and widening blood vessels by blocking the entry of calcium into the smooth muscle cells of blood vessel walls. Valsartan is an angiotensin II receptor blocker that blocks the action of a naturally occurring hormone called angiotensin II, which normally constricts blood vessels and raises blood pressure. By blocking this hormone, valsartan also allows blood vessels to relax and widen. Together, these two actions allow blood to flow more easily and help lower blood pressure.
Drug interactions
aliskiren; lithium; potassium supplements; potassium-sparing diuretics; non-steroidal anti-inflammatory drugs; ACE inhibitors; heparin; grapefruit juice; CYP3A4 inhibitors; CYP3A4 inducers; simvastatin; dantrolene; other antihypertensives
Age restrictions
Safety and efficacy in children and adolescents under 18 years have not been established. Caution required when increasing dosage in elderly patients.
Pregnancy and breastfeeding
Pregnancy: Amlodipine may be used during pregnancy if clinically needed. Valsartan is contraindicated during the second and third trimesters of pregnancy. Angiotensin II receptor antagonists should not be initiated during pregnancy. When pregnancy is diagnosed, Exforge must be discontinued immediately and alternative antihypertensive therapy started. Breastfeeding: Not recommended; alternative treatments with better established safety profiles during breast-feeding are preferable.
FAQ
Will I receive the original Exforge?
No. Exforge is the original brand, made by Novartis, and Direct Meds uses the name to identify the medicine: you receive a generic with the same active ingredients (amlodipine and valsartan) at the same strength. The generic brand and manufacturer depend on available stock.
How is Exforge priced?
It depends on the pack size. Exforge comes in a 5mg + 80mg strength, in packs of 20 to 120 tablets, and the price of every option is shown above. Prices are set in US dollars and converted. Larger packs cost less per tablet.
Payment and prices →What other names is Exforge sold under?
Other brand names for amlodipine and valsartan include Dafiro. In South Africa, amlodipine and valsartan are also sold under brand names such as Valduo, Copalia and Calsar.
What is Exforge used for?
Exforge contains amlodipine and valsartan, used for hypertension.
What are the side effects of Exforge?
The common side effects of amlodipine and valsartan are peripheral oedema, headache, dizziness, fatigue, nasopharyngitis and upper respiratory tract infection. Less common ones include hypotension, orthostatic hypotension, syncope, hyperkalaemia, renal impairment and angina pectoris. Serious but less common side effects include angioedema, myocardial infarction, severe hypotension and acute renal failure, which need urgent medical attention.
What does Exforge interact with?
Amlodipine and valsartan can interact with aliskiren, lithium, potassium supplements, potassium-sparing diuretics, non-steroidal anti-inflammatory drugs and ACE inhibitors. Tell your doctor or pharmacist about every medicine you take before you start taking Exforge.
Do I need a prescription to buy Exforge in South Africa?
No, not online: Direct Meds does not ask for a prescription to order Exforge. We are a broker, not a dispensing pharmacy. We arrange orders and delivery with our affiliated supplier on your behalf.
Ordering without a prescription →Where can I buy Exforge in South Africa?
On Direct Meds: choose the strength and pack, then check out. Our affiliated supplier delivers across South Africa. Estimated delivery is 7 days with Express Delivery, which includes online tracking, or up to 3 weeks with Regular Delivery.
How ordering works →What you will receive
Exforge names the medicine you are looking for. What ships is a generic version of it.
- A generic containing Amlodipine / Valsartan at the strength you pick.
- Which generic brand and maker ships depends on stock and destination.
- Check the active ingredient, strength, form, pack, seal, batch and expiry when it arrives.