Avanafil
Avanafil is a phosphodiesterase type 5 inhibitor used for erectile dysfunction. One product appears here: Avana, in 50 mg, 100 mg and 200 mg tablets.
Key points
- Do not take avanafil with organic nitrates in any form. The label states this combination is contraindicated because avanafil can amplify the blood pressure drop caused by nitrates.
- An erection lasting longer than 4 hours needs immediate medical attention; without prompt treatment it can cause permanent tissue damage.
- Headache, flushing, nasal congestion and back pain occur in 2% or more of patients in trials.
How does Avanafil work?
Avanafil blocks the enzyme phosphodiesterase type 5, which breaks down a signal that relaxes blood vessels in the penis. With that signal sustained, blood flow increases during sexual stimulation. Avanafil does not cure erectile dysfunction or raise sexual desire on its own. The liver clears it mainly through the CYP3A4 enzyme. Avana supplies avanafil alone; the combination product Super Avana pairs it with dapoxetine, a short-acting SSRI.
Further reading
What is avanafil used for?
Avanafil is a phosphodiesterase type 5 inhibitor used for erectile dysfunction. It blocks the enzyme phosphodiesterase type 5, which breaks down a signal that relaxes blood vessels in the penis, so blood flow increases during sexual stimulation. It does not cure erectile dysfunction or raise sexual desire on its own.
How long does avanafil take to work and how long does it last?
Avanafil takes 15 to 30 minutes to start working and its effect lasts 4 to 6 hours.
What are the side effects of avanafil?
Headache, flushing and nasal congestion are common side effects of avanafil. Dizziness, back pain and indigestion (dyspepsia) can also occur. Priapism and sudden hearing loss are serious side effects that need immediate medical attention, so speak to a doctor or pharmacist if they occur.
Can avanafil be taken with other medicines?
Avanafil interacts with nitrates, amlodipine and ketoconazole. Do not take avanafil with organic nitrates in any form because this combination is contraindicated and can amplify the blood pressure drop caused by nitrates. Ask a doctor or pharmacist before taking it with other medicines.
Who should not take avanafil?
Avanafil should not be used concurrently with nitrates, or in severe cardiovascular disease or severe hepatic impairment. Do not take avanafil with organic nitrates in any form.
Which avanafil products does Direct Meds sell?
On Direct Meds, avanafil comes as Avana. Compare their forms, strengths and packs.
How much does avanafil cost in South Africa?
Compare the rand prices for each product, strength and pack above. Prices are converted from US dollars. Larger packs usually cost less per tablet.
Payment and prices →Is avanafil available over the counter in South Africa?
Yes, online. Direct Meds does not ask for a prescription to order avanafil. We are a broker, not a dispensing pharmacy. We arrange orders and delivery with our affiliated supplier on your behalf.
Ordering without a prescription →Can I buy avanafil online in South Africa?
Yes. Our affiliated supplier delivers across South Africa. Estimated delivery is 7 days with Express Delivery, which includes online tracking, or up to 3 weeks with Regular Delivery.
How ordering works →