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Cenforce D (Dapoxetine; Sildenafil) Buyer and Patient Handbook in South Africa

What is Cenforce D?

Cenforce D is a combined tablet containing dapoxetine 100 mg and sildenafil 60 mg, used to treat premature ejaculation (PE) and Erectile Dysfunction (ED) in adult men. It belongs to the selective serotonin re-uptake inhibitor (SSRI) class (dapoxetine) and the phosphodiesterase-5 inhibitor class (sildenafil). The product is approved by the South African Health Products Regulatory Authority (SAHPRA) and is supplied as a swallow-whole pill.

Who Should Use Cenforce D?

• Men ≥ 18 years with a documented diagnosis of PE and concurrent ED.
• Individuals who have responded to separate dapoxetine and sildenafil therapy but prefer a single-dose regimen.
• Patients without uncontrolled hypertension, severe cardiovascular disease, or contraindicated medication use (see Contraindications).

How Does It Work?

Dapoxetine blocks serotonin re-uptake in the central nervous system, delaying ejaculation by enhancing serotonergic inhibition. Sildenafil inhibits phosphodiesterase-5, facilitating penile erection by increasing cyclic-GMP levels in response to sexual stimulation. Together, they enable a sustained erection while extending ejaculatory control, allowing more satisfying sexual activity.

Why Choose Cenforce D?

• Convenient dual therapy eliminates the need for two separate tablets.
• Dapoxetine’s short half-life (≈ 1-2 h) limits lingering side effects, while sildenafil’s well-studied efficacy ensures reliable erections.
• Generic formulation offers a cost-effective alternative to brand-only products, while maintaining bioequivalence to reference medicines.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• One tablet (100 mg dapoxetine + 60 mg sildenafil) taken orally about 1 hour before sexual activity.
• Do not exceed one tablet per day.

How to Take

1. Swallow the tablet whole with a glass of water.
2. Take it on an empty stomach or with a light meal; heavy or fatty meals may delay sildenafil absorption.
3. Ensure you have sexual stimulation for the medication to work.

Missed Dose

• If you miss a planned dose, do not take a second tablet later that day. Wait until the next opportunity to have sexual activity and then take one tablet as directed.

Overdose

• Call emergency services or go to the nearest hospital if you suspect an overdose (e.g., more than one tablet).
• Symptoms may include severe headache, dizziness, priapism, or fainting.

Special Populations

• Elderly (≥ 65 years): Start with a lower sildenafil dose (e.g., 25 mg) if tolerated, while keeping dapoxetine at 100 mg.
• Renal or hepatic impairment: Consult a healthcare professional; dose adjustments may be required.
• Women and children: Not indicated.

Lifestyle & Diet

• Avoid excessive alcohol (≥ 3 units) as it can reduce efficacy and increase side effects.
• No grapefruit juice within 24 h; it can raise sildenafil levels.
• Continue regular exercise; however, refrain from high-intensity activity within 2 h of dosing if you feel light-headed.

Precautions and Warnings

• Do not use with nitrates (e.g., nitroglycerin) or nitric-oxide donors; the combination can cause life-threatening hypotension.
• Caution in men with unstable Angina, recent myocardial infarction, or severe heart failure.
• Monitor blood pressure; avoid use if systolic < 90 mm Hg or diastolic < 50 mm Hg.
• Report any visual disturbances (e.g., blurred vision) or sudden hearing loss immediately.

Drug Interactions

Potential Side Effects

Common Side Effects

• Headache, flushing, nasal congestion, dyspepsia, dizziness, mild nausea.

Less Common Side Effects

• Vision changes (blurred vision, blue-tinted vision), tinnitus, back Pain, muscle aches.

Serious Side Effects

• Priapism lasting > 4 hours, sudden loss of vision, sudden hearing loss, severe hypotension, chest pain. Seek immediate medical attention if any occur.

Who Should Avoid This Medication?

• Men with contraindicated nitrate therapy.
• Those with severe cardiovascular disease (unstable angina, recent MI, severe Heart Failure).
• Patients with severe hepatic or renal impairment without dose adjustment.
• Individuals with known hypersensitivity to dapoxetine, sildenafil, or any excipients.

Storage Instructions

• Keep the blister pack in a dry place at temperatures 15 °C-30 °C; protect from moisture and direct sunlight.
• Keep out of reach of children and pets.
• Do not use after the expiry date printed on the pack.

Cenforce D Alternatives

Frequently Asked Questions

How soon before sex should I take Cenforce D?

Take the tablet about 1 hour prior to anticipated sexual activity; it can be effective up to 4 hours later.

Can I take Cenforce D with alcohol?

A small amount of alcohol is acceptable, but excessive drinking may diminish efficacy and increase dizziness.

Is it safe to use Cenforce D if I have high blood pressure?

If your blood pressure is well-controlled and you are not on nitrates, Cenforce D can be used, but monitor your BP and discuss with a healthcare professional.

Will Cenforce D cause permanent changes to my libido?

No. The medication temporarily enhances erection and delays ejaculation; it does not cause lasting hormonal or libido changes.

What should I do if I experience a painful erection lasting more than 4 hours?

This is priapism-seek emergency medical care immediately to prevent tissue damage.

Can I use Cenforce D if I am taking antidepressants?

Certain antidepressants (especially SSRIs) may increase dapoxetine levels; consult a healthcare professional before combining.

Does smoking affect the effectiveness of Cenforce D?

Smoking can impair vascular health and may reduce erectile response; quitting improves overall outcomes.

Is Cenforce D available over the counter in South Africa?

No. It is a prescription-only medicine in South Africa, intended for use under professional guidance.

How long can I use Cenforce D safely?

Long-term safety data is limited; typically, intermittent use (as needed) is recommended. Discuss continuous therapy with a clinician.

Will taking Cenforce D affect my ability to drive or operate machinery?

Mild dizziness or visual changes may occur; avoid driving if you feel impaired after dosing.

Glossary

• Selective Serotonin Re-uptake Inhibitor (SSRI): A drug that blocks serotonin re-absorption, enhancing its action in the brain.
• Phosphodiesterase-5 (PDE5) Inhibitor: A medication that enhances blood flow to the penis by preventing the breakdown of cyclic-GMP.
• Priapism: A painful, prolonged erection lasting more than 4 hours, requiring urgent treatment.

Disclaimer

The information provided here is for general educational purposes only and does not replace professional medical advice. Off-label use, dosage changes, or combination with other medicines should only be considered after consulting a qualified healthcare provider. Our service offers a convenient platform to access legally approved medicines in South Africa, but the ultimate responsibility for safe use lies with the patient. Always seek personalized counsel from a doctor or pharmacist before starting any new treatment.