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Crestor (Rosuvastatin) Buyer and Patient Handbook in South Africa

What is Crestor?

Crestor is a rosuvastatin-based tablet used to lower High Cholesterol and triglycerides. It belongs to the statin class of lipid-lowering agents and is prescribed for primary and secondary Prevention of Cardiovascular Disease. The medication is approved by SAHPRA, the FDA, and the EMA and is marketed in 5 mg, 10 mg, and 20 mg pill strengths.

Who Should Use Crestor?

• Adults with elevated LDL-cholesterol, non-HDL cholesterol, or triglycerides
• Patients with documented atherosclerotic cardiovascular disease (ASCVD)
• Individuals with familial hypercholesterolaemia
• Those who need additional lipid control despite lifestyle measures

How Does It Work?

Crestor blocks the enzyme HMG-CoA reductase, which the liver uses to produce cholesterol, thereby reducing the amount of LDL-cholesterol released into the bloodstream. Think of the enzyme as a factory line; Crestor stops the line, so fewer cholesterol particles are made. The drug has a low risk of dependence and is not a controlled substance.

Why Choose Crestor?

Crestor offers potent LDL-cholesterol reduction-up to 55 % at the 20 mg dose-making it one of the strongest statins available. The brand formulation provides consistent bioavailability, while generic rosuvastatin offers a cost-effective alternative with the same therapeutic effect. Off-label uses (e.g., certain liver disorders) should be discussed with a qualified health professional.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• 5 mg once daily (initial therapy or modest LDL-C reduction)
• 10 mg once daily (moderate reduction)
• 20 mg once daily (intensive reduction)

How to Take

Swallow the tablet whole with a glass of water, preferably at the same time each day; it can be taken with or without food.

Missed Dose

If you remember the missed dose within 12 hours, take it now; otherwise skip it and resume the regular schedule. Do not double-dose.

Overdose

Seek urgent medical attention if you suspect an overdose. Symptoms may include muscle Pain, weakness, or dark urine.

Special Populations

• Elderly: Start with 5 mg; monitor renal function.
• Renal impairment: Dose may need reduction; avoid if creatinine clearance <30 mL/min.
• Pregnancy & lactation: Generally contraindicated; discuss alternatives with a health professional.

Lifestyle & Diet

• Avoid excessive grapefruit juice, which can increase drug levels.
• Maintain a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins.
• Regular exercise amplifies lipid-lowering effects.

Precautions and Warnings

• Do not use if you have active liver disease or persistent elevations of transaminases.
• Screen for hepatitis B/C and HIV before initiating therapy.
• Monitor for signs of Myopathy (muscle pain, tenderness) especially if combined with strong CYP3A4 inhibitors.

Drug Interactions

Potential Side Effects

Common Side Effects

• Headache
• Nausea or abdominal discomfort
• Mild muscle aches

Less Common Side Effects

• Elevated liver enzymes
• Constipation or diarrhoea
• Dizziness

Serious Side Effects

• Severe muscle breakdown (rhabdomyolysis) - seek immediate care if you notice dark urine or profound muscle pain.
• Acute liver failure - stop medication and obtain urgent medical evaluation if jaundice develops.

Who Should Avoid This Medication?

• Known hypersensitivity to rosuvastatin or any tablet excipients
• Active liver disease or unexplained persistent ALT/AST elevations
• Pregnant or breastfeeding women

Storage Instructions

• Keep the bottle tightly closed at room temperature (15 °C-30 °C).
• Protect from moisture and direct sunlight.
• Store out of reach of children and pets.

Crestor Alternatives

Frequently Asked Questions

How long does it take for Crestor to lower cholesterol?

Most patients see a measurable reduction within 2 weeks, with maximum effect at 4-6 weeks.

Can I drink alcohol while taking Crestor?

Moderate alcohol intake is permissible, but excessive drinking may increase liver-enzyme elevations.

Will Crestor interact with my coffee habit?

Regular coffee consumption does not affect rosuvastatin levels.

What should I do if I experience muscle pain?

Stop the medication and contact a health professional promptly to assess for myopathy.

Is it safe to switch from another statin to Crestor?

Yes, but a clinician should guide the transition to avoid overlapping high doses.

Do I need regular blood tests while on Crestor?

Baseline liver enzymes and lipid profile are recommended, followed by periodic monitoring every 3-12 months.

Can Crestor be taken with over-the-counter supplements?

Some supplements (e.g., red yeast rice) contain statin-like substances and may increase muscle-toxicity risk; discuss any supplement use with a health professional.

What happens if I miss several doses?

Contact a health professional for advice; they may suggest restarting at a lower dose and re-checking lipid levels.

Glossary

• LDL-C (Low-Density Lipoprotein Cholesterol): The “bad” cholesterol that contributes to plaque buildup in arteries.
• Statin: A class of drugs that inhibit HMG-CoA reductase, reducing cholesterol synthesis.
• Rhabdomyolysis: A rare but serious condition where muscle tissue breaks down, releasing harmful proteins into the bloodstream.

Disclaimer

The information provided is for educational purposes only and does not replace professional medical advice. Off-label uses should be discussed with a qualified health professional. Readers are responsible for verifying the suitability of Crestor for their individual health needs. Our online pharmacy platform offers convenient access to approved medicines, but all purchases must comply with South African regulations and require a valid prescription from a licensed practitioner.