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Lioresal (Baclofen) Buyer and Patient Handbook in South Africa

Lioresal (Baclofen) is a muscle-relaxant medication used to treat Spasticity caused by conditions such as Multiple Sclerosis, spinal cord injury, or cerebral palsy. It belongs to the muscle relaxant class and is authorised by the South African Health Products Regulatory Authority (SAHPRA). The product is supplied as oral tablets.

Medication Overview

Lioresal is indicated for the reduction of muscle tone in patients with spasticity of central origin. It helps improve mobility and daily functioning by relaxing over-active muscles.

Who Is It Intended For?

• Adults with spasticity secondary to multiple sclerosis, spinal cord injury, or cerebral palsy.
• Individuals who require a systemic oral therapy rather than injectable options.
• Patients whose spasticity is not adequately controlled with physiotherapy alone.

How It Works

Lioresal (baclofen) binds to GABA-B receptors in the spinal cord, inhibiting the release of excitatory neurotransmitters and reducing nerve-signal transmission that causes muscle stiffness. This action is similar to applying a gentle brake on a vehicle that is constantly accelerating: it slows excessive muscle contractions without stopping normal movement.

Why Choose Lioresal?

• Generic availability means lower cost compared with brand-only options.
• Well-studied safety profile and predictable onset of action.
• Can be taken at home, supporting independence.

Off-label use should only be considered after consulting a qualified health professional.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• 10 mg tablet taken once daily (usually as a starting dose).
• 25 mg tablet taken once or twice daily based on clinical response.

How to Take

1. Swallow the tablet whole with a glass of water.
2. Take the medication at the same times each day to maintain steady blood levels.
3. It can be taken with or without food; however, a light snack may reduce stomach upset.

Missed Dose

If a dose is missed, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose - do not double-dose.

Overdose

Seek immediate medical attention if more than the prescribed amount is taken. Symptoms may include severe Drowsiness, muscle weakness, or respiratory Depression.

Special Populations

• Elderly: Start with the lowest dose (10 mg) and increase slowly.
• Renal impairment: Dose reduction is recommended; monitor kidney function.
• Pregnancy & breastfeeding: Use only if clearly needed and after risk-benefit assessment.

Lifestyle & Diet

• Avoid large quantities of grapefruit juice, which can increase baclofen levels.
• Limit alcohol intake, as it can enhance central nervous system depression.
• Maintain regular physiotherapy to maximise functional gains.

Precautions and Warnings

• Do not discontinue abruptly; taper the dose to avoid withdrawal symptoms such as Seizures or hallucinations.
• Caution in patients with a history of seizures, depression, or respiratory disorders.
• Use with care when operating machinery or driving, especially during dose titration.

Drug Interactions

Potential Side Effects

Common Side Effects

• Drowsiness
• Dizziness
• Weakness or Fatigue

Less Common Side Effects

• Nausea
• Headache
• Dry mouth

Serious Side Effects

• Severe muscle weakness or paralysis
• Rapid heart rate or irregular rhythm
• Hallucinations or confusion - seek medical help immediately

Who Should Avoid This Medication?

• Known hypersensitivity to baclofen or any tablet excipients.
• Severe Renal Failure without dose adjustment.
• Uncontrolled Epilepsy, as abrupt changes may precipitate seizures.

Storage Instructions

• Keep tablets in a cool, dry place below 25 °C (77 °F).
• Store out of reach of children and pets.
• Do not freeze or expose to direct sunlight.

Lioresal Alternatives

Frequently Asked Questions

How long does it take to feel the effects?

Most patients notice a reduction in spasm severity within 3-5 days of reaching an effective dose.

Can I take Lioresal with coffee?

Moderate caffeine intake generally does not interfere, but excessive amounts may increase jitteriness.

What should I do if the tablets make me too sleepy?

Report the symptom to your healthcare provider; a dose reduction or timing adjustment may help.

Is it safe to drive while on Lioresal?

Avoid driving or operating heavy machinery until you know how the medication affects you, especially during the first few weeks.

Can I use Lioresal for muscle cramps?

Lioresal is not indicated for isolated cramps; discuss alternative options with a professional.

What happens if I forget a dose for several days?

Contact a healthcare provider before restarting; a gradual re-initiation may be necessary.

Is there a risk of dependence?

Physical dependence can develop with prolonged high-dose use; tapering under supervision reduces this risk.

How does kidney function affect dosing?

Reduced renal clearance requires lower dosing and careful monitoring to avoid accumulation.

Glossary

• Spasticity: Muscle stiffness and involuntary contractions due to nerve damage.
• GABA-B receptor: A type of receptor that inhibits nerve activity, leading to muscle relaxation.
• Tapering: Gradual reduction of medication dose to prevent withdrawal.

Disclaimer

The information provided here is for educational purposes only and does not replace professional medical advice. Off-label use, dosage adjustments, and any health decisions should be discussed with a qualified health practitioner. Our online pharmacy service offers verified medication sourcing in South Africa, but the ultimate responsibility for safe use lies with the reader. Always consult a health professional before starting or changing any medication regimen.