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Nexium (Esomeprazole) Buyer and Patient Handbook in South Africa

What is Nexium?

Nexium is a proton-pump inhibitor (PPI) used to reduce stomach acid and treat conditions such as gastro-oesophageal reflux disease (GERD) and peptic ulcers. It belongs to the gastrointestinal medication class and is approved by the South African Health Products Regulatory Authority (SAHPRA). Nexium is available as an oral pill in strengths of 20 mg and 40 mg.

Who Should Use Nexium?

• Adults diagnosed with GERD, erosive oesophagitis, or Zollinger-Ellison Syndrome.
• Patients who need ulcer healing after non-steroidal anti-inflammatory drug (NSAID) use.
• Individuals with confirmed excessive gastric acid secretion.

How Does It Work?

Nexium blocks the H⁺/K⁺-ATPase enzyme (the “acid pump”) in the stomach lining, preventing the final step of acid production. By lowering acid, it relieves heartburn, allows damaged tissue to heal, and reduces the risk of ulcer complications. Safety note: Nexium has a low potential for abuse, but long-term use should be medically supervised.

Why Choose Nexium?

Nexium provides rapid and sustained acid suppression, often achieving symptom relief within 1 - 2 days. The brand formulation delivers consistent bioavailability, while generic esomeprazole options are available for cost-effective treatment. Off-label uses, such as for dyspepsia, should only be considered after professional advice.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• 20 mg once daily for mild-to-moderate GERD.
• 40 mg once daily for severe disease or ulcer healing.

How to Take

• Swallow the tablet whole with a full glass of water.
• Take on an empty stomach, preferably 30-60 minutes before breakfast.

Missed Dose

• If you remember within 12 hours, take it immediately.
• If it is longer than 12 hours, skip the missed dose and resume your regular schedule.

Overdose

• Seek medical help promptly if you suspect an overdose.
• Supportive care, such as monitoring heart rhythm, is the usual treatment.

Special Populations

• Elderly: Start with the lowest effective dose; monitor kidney function.
• Renal impairment: Dose adjustment may be required; consult a healthcare professional.
• Pregnancy & breastfeeding: Use only if clearly needed; discuss risks with a clinician.

Lifestyle & Diet

• Avoid taking Nexium with antacids, as they may reduce absorption.
• Limit grapefruit juice, which can increase esomeprazole levels.
• Maintain a balanced diet and avoid late-night meals that aggravate reflux.

Precautions and Warnings

• Use the lowest effective dose for the shortest duration needed.
• Long-term therapy may be linked to vitamin B12 deficiency, magnesium loss, and increased risk of bone fractures; periodic monitoring is advised.
• Inform your healthcare provider of any liver disease, as dose adjustment may be necessary.

Drug Interactions

Potential Side Effects

Common Side Effects

• Headache
• Diarrhoea or constipation
• abdominal Pain

Less Common Side Effects

• Nausea
• Flatulence
• Dizziness

Serious Side Effects

• Severe allergic reaction (rash, swelling, difficulty breathing) - seek emergency care
• Persistent vomiting or diarrhoea leading to dehydration - contact a clinician
• Signs of low magnesium (muscle cramps, irregular heartbeat) - request testing

Who Should Avoid This Medication?

• Known hypersensitivity to esomeprazole or any PPI component.
• Patients with severe liver disease without specialist guidance.
• Individuals with a history of Clostridioides difficile Infection should use caution.

Storage Instructions

• Keep tablets in the original container, tightly closed.
• Store at room temperature (15-30 °C) away from moisture and direct sunlight.
• Keep out of reach of children.

Nexium Alternatives

Frequently Asked Questions

How quickly will Nexium relieve my heartburn?

Most patients notice improvement within 1 - 2 days of starting therapy.

Can I take Nexium with coffee or alcohol?

Moderate coffee and alcohol are acceptable, but excessive consumption may worsen reflux symptoms.

What should I do if I experience no relief after a week?

Contact a healthcare professional to review your diagnosis and consider dose adjustment or alternative treatment.

Is it safe to use Nexium for more than six months?

Long-term use is possible but requires periodic monitoring for nutrient deficiencies and bone health.

Can I switch from a generic to the brand version without a doctor’s input?

While both contain the same active ingredient, discuss any switch with a qualified professional to ensure appropriate dosing.

Will Nexium interfere with my cholesterol medication?

Nexium has low interaction potential with most statins, but verify with your prescriber if you use high-dose Simvastatin.

Is Nexium suitable for children?

It is not recommended for children under 12 years without specialist advice.

How should I store Nexium while traveling?

Keep the bottle sealed, avoid extreme temperatures, and carry it in your hand-luggage rather than checked baggage.

Glossary

• Proton-pump inhibitor (PPI): A drug class that blocks the final step of stomach acid production.
• GERD: Gastro-oesophageal reflux disease, a chronic condition where stomach acid flows back into the oesophagus.
• Bioavailability: The proportion of a drug that enters circulation and can have an active effect.

Disclaimer

This handbook provides general information about Nexium and is not a substitute for professional medical advice. Off-label uses should only be undertaken after discussion with a qualified healthcare provider. The content reflects current knowledge and may change; always verify details with a trusted source. Our online pharmacy offers convenient access to approved medications, but the responsibility for safe use rests with the individual. Consult a qualified health professional before starting or stopping any medication.