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Pentasa (Mesalamine) Buyer and Patient Handbook in South Africa

What is Pentasa?

Pentasa is an oral mesalamine tablet belonging to the 5-aminosalicylic acid (5-ASA) class, used to treat Inflammatory Bowel Disease, principally Ulcerative Colitis and Crohn’s disease affecting the colon. It is approved by the South African Health Products Regulatory Authority (SAHPRA) and is available in 400 mg tablets.

Who Should Use Pentasa?

• Adults diagnosed with ulcerative colitis or Crohn’s disease limited to the colon.
• Patients seeking maintenance therapy to keep disease in remission.
• Individuals who can swallow tablets whole and have no known hypersensitivity to salicylates.

How Does It Work?

Mesalamine released from Pentasa acts locally on the intestinal lining, inhibiting inflammatory mediators such as prostaglandins and leukotrienes. By reducing inflammation, it helps prevent flare-ups and promotes healing of the colon’s mucosa. It is not a narcotic and has no abuse potential.

Why Choose Pentasa?

• Targeted release: The tablet’s coating ensures the drug reaches the colon, where it is needed most.
• Proven efficacy: Clinical trials show Pentasa effectively maintains remission in ulcerative colitis and Crohn’s disease.
• Generic alternative: A bio-equivalent mesalamine generic is available at lower cost, offering the same therapeutic benefit.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• 400 mg tablet taken twice daily (total 800 mg per day). Adjustments may be made by a qualified health professional.

How to Take

• Swallow the tablet whole with a full glass of water.
• Do not crush, chew, or split the tablet; the coating is essential for colonic delivery.

Missed Dose

• Take the missed dose as soon as you remember unless it is almost time for your next dose. In that case, skip the missed tablet and resume your regular schedule. Do not double-dose.

Overdose

• If you suspect an overdose, seek immediate medical attention or call emergency services. Symptoms may include nausea, vomiting, abdominal Pain, or dizziness.

Special Populations

• Elderly: No dose reduction required, but monitor renal function.
• Renal impairment: Use with caution; dose may need adjustment.
• Pregnancy & breastfeeding: Discuss risks and benefits with your health-care provider; mesalamine is generally considered low risk, but professional guidance is essential.

Lifestyle & Diet

• Food: Can be taken with or without meals.
• Grapefruit: No known interaction, but maintain a balanced diet.
• Alcohol: Moderate intake is acceptable; excessive alcohol may exacerbate gastrointestinal symptoms.

Precautions and Warnings

• Avoid use if you have a known allergy to mesalamine, sulfasalazine, or other salicylates.
• Monitor kidney function periodically, especially if you have pre-existing renal disease.
• Report any sudden worsening of abdominal pain, bloody stools, or fever to a health professional promptly.

Drug Interactions

Potential Side Effects

Common Side Effects

• Headache
• Nausea
• Abdominal cramping

Less Common Side Effects

• Mild rash or itching
• Flatulence
• Loose stools

Serious Side Effects

• Severe abdominal pain with fever
• Persistent bloody Diarrhea
• Signs of kidney trouble (e.g., reduced urine output)

If any serious effect occurs, seek medical attention immediately.

Who Should Avoid This Medication?

• Individuals with hypersensitivity to mesalamine or any 5-ASA compound.
• Patients with a history of acute severe ulcerative colitis flare requiring hospitalization.
• Those with severe renal impairment unless closely supervised.

Storage Instructions

• Keep tablets in the original container, tightly closed.
• Store at room temperature (15-30 °C), away from moisture and direct sunlight.
• Keep out of reach of children and pets.

Pentasa Alternatives

Frequently Asked Questions

How quickly can I expect symptom relief?

Most patients notice improvement within 2-4 weeks of consistent use, though full remission may take longer.

Can I take Pentasa with caffeine?

Yes, moderate caffeine consumption does not affect Pentasa’s efficacy.

Is it safe to use Pentasa while traveling abroad?

Absolutely, as long as you keep the medication in its original packaging and store it at ambient temperature.

What should I do if I experience persistent nausea?

Try taking the tablet with a meal or a larger glass of water. If nausea continues, contact a health professional.

Does Pentasa interact with antacids?

Antacids may reduce absorption; separate dosing by at least 2 hours.

Can I switch from a brand to a generic mesalamine?

Yes, generic mesalamine is bio-equivalent. Discuss the switch with your health-care provider to ensure proper dosing.

What happens if I miss several doses?

Missing multiple doses may increase the risk of a disease flare. Resume the prescribed schedule as soon as possible and inform your provider.

Is there any need for routine blood tests?

Periodic monitoring of renal function and blood counts is advisable, especially in long-term therapy.

Glossary

• 5-ASA (5-Aminosalicylic Acid): A class of anti-inflammatory drugs that act locally in the gut.
• Bio-equivalent: A generic product shown to deliver the same amount of active ingredient into the bloodstream as the brand name.
• Flare-up: A sudden worsening of disease symptoms, such as increased abdominal pain or bloody stools.

Disclaimer

The information provided here is for general educational purposes only and does not replace professional medical advice. All off-label uses, dosage adjustments, and treatment decisions should be discussed with a qualified health-care provider. Our service offers convenient access to approved medicines; however, the ultimate responsibility for safe use rests with the patient. Always consult a health professional before starting or changing any medication.