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Top Avana (Dapoxetine; Avanafil) Buyer and Patient Handbook in South Africa

What is Top Avana?

Top Avana is a combined pill that contains dapoxetine and avanafil, belonging to the selective serotonin-reuptake inhibitor (SSRI) class and the phosphodiesterase-5 (PDE5) inhibitor class, respectively. It is approved by SA Health (SAHPRA) for the treatment of premature ejaculation and Erectile Dysfunction in adult men. The tablet is available in a fixed-dose of 30 mg dapoxetine / 50 mg avanafil.

Who Should Use Top Avana?

• Men ≥ 18 years experiencing premature ejaculation.
• Men ≥ 18 years with diagnosed erectile dysfunction.
• Individuals who are otherwise healthy and have stable cardiovascular status.

How Does It Work?

Dapoxetine blocks the re-uptake of serotonin, extending the time before ejaculation occurs. Avanafil enhances blood flow to the penis by inhibiting the PDE5 enzyme, allowing an erection to develop when sexual stimulation is present. Together they address both timing and rigidity, giving a more complete sexual response. Do not use if you have uncontrolled hypertension or recent Heart Attack.

Why Choose Top Avana?

• Convenient dual action - one tablet treats two common male sexual concerns.
• Rapid onset - avanafil works within 15 minutes, dapoxetine within 1-2 hours.
• Cost-effective compared with buying two separate products. Off-label uses (e.g., for Anxiety) should only be considered after professional advice.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• 30 mg dapoxetine / 50 mg avanafil taken as a single tablet.
• Do not exceed one tablet per day.

How to Take

• Swallow the tablet whole with a full glass of water.
• Take it 30 minutes to 2 hours before anticipated sexual activity.
• Food does not significantly affect absorption, but a heavy, fatty meal may delay avanafil’s onset slightly.

Missed Dose

• If you forget to take the tablet and sexual activity is still planned, take it as soon as you remember provided at least 12 hours have passed since the previous dose.
• Do not double the dose to catch up.

Overdose

• Call emergency services (112 in South Africa) immediately.
• Symptoms may include dizziness, low blood pressure, prolonged erection, or severe headache.

Special Populations

• Elderly (≥ 65 years): start with the lowest available dose; monitor blood pressure.
• Renal or hepatic impairment: dose adjustment may be required; consult a healthcare professional.
• Children and adolescents: not recommended.

Lifestyle & Diet

• Avoid grapefruit or grapefruit juice within 24 hours, as it can increase avanafil levels.
• Limit alcohol to moderate amounts; excessive intake may exacerbate side-effects.
• Do not use recreational nitrates (e.g., “poppers”) as they can cause severe blood-pressure drops.

Precautions and Warnings

• Do not use if you have a history of cardiovascular disease, uncontrolled hypertension, or are on nitrates.
• Inform your clinician of any psychiatric conditions or use of other SSRIs, as serotonin syndrome is possible.
• Monitor for visual disturbances or hearing loss; discontinue and seek help if they occur.

Drug Interactions

Potential Side Effects

Common Side Effects

• Headache
• Flushing
• Nasal congestion
• Nausea

Less Common Side Effects

• Dizziness
• Diarrhoea
• Back Pain

Serious Side Effects

• Chest pain or prolonged erection (> 4 hours) - seek medical help immediately.
• Severe allergic reaction (rash, swelling, breathing difficulty).

Who Should Avoid This Medication?

• Anyone taking nitrates (including recreational “poppers”).
• Men with severe uncontrolled hypertension (> 180/110 mmHg).
• Patients with recent myocardial infarction or stroke (within 6 months).
• Individuals with retinitis pigmentosa or other inherited retinal diseases.

Storage Instructions

• Keep the tablet in its original blister pack.
• Store at 15 °C-30 °C, away from direct sunlight and moisture.
• Keep out of reach of children and pets.

Top Avana Alternatives

Frequently Asked Questions

How soon before sex should I take Top Avana?

Take the tablet 30 minutes to 2 hours beforehand; avanafil works within 15 minutes, dapoxetine within 1-2 hours.

Can I take Top Avana with alcohol?

Moderate alcohol is acceptable, but excessive drinking may increase dizziness and lower blood pressure.

Is it safe to use Top Avana if I have high blood pressure?

Only if your blood pressure is well-controlled (< 140/90 mmHg). Uncontrolled hypertension is a contraindication.

Will the medication affect my fertility?

No evidence suggests that dapoxetine or avanafil impair sperm production or quality.

Can I use Top Avana with other antidepressants?

Concurrent use with other SSRIs or MAO-inhibitors may raise the risk of serotonin syndrome; consult a clinician before combining.

What should I do if I experience a prolonged erection?

If an erection lasts more than 4 hours, seek emergency medical attention (call 112).

Is there any risk of dependency?

Dapoxetine is not habit-forming, and avanafil does not cause physiological dependence. Psychological reliance can occur with any sexual aid and should be discussed with a healthcare provider.

Can I take Top Avana daily?

The product is intended for as-needed use. Daily dosing is not recommended without medical supervision.

How does Top Avana compare to taking two separate pills?

It offers convenience and potentially lower cost, with similar efficacy when the individual components are taken at the same doses.

Is Top Avana available over the counter in South Africa?

It is a prescription-only medicine in South Africa; a qualified healthcare professional must assess suitability before supply.

Glossary

• Selective serotonin-reuptake inhibitor (SSRI): A drug class that increases serotonin levels in the brain, delaying ejaculation.
• Phosphodiesterase-5 (PDE5) inhibitor: A drug that enhances blood flow to the penis, facilitating erection.
• Serotonin syndrome: A rare but serious condition caused by excess serotonin, presenting with Agitation, rapid heart rate, and high temperature.

Disclaimer

The information provided here is for general educational purposes only and does not replace professional medical advice. Off-label use, dosage adjustments, and individual health considerations should be discussed with a qualified healthcare provider. Our service offers a convenient platform to purchase medicines that are legally supplied in South Africa; however, the responsibility for safe and appropriate use rests with the reader. Always consult a doctor or pharmacist before starting any new medication.