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Wellbutrin (Bupropion) Buyer and Patient Handbook in South Africa

What is Wellbutrin?

Wellbutrin is a bupropion-based oral medication classified as an atypical antidepressant. It is approved for the treatment of Major Depressive Disorder and to help people stop smoking. The product is available as a pill and meets South African Health Products Regulatory Authority (SAHPRA) standards.

Who is Wellbutrin for?

• Adults diagnosed with major depressive disorder.
• Adults seeking assistance with Smoking Cessation.
• Individuals without a history of Seizures or eating disorders.

How does Wellbutrin work?

Wellbutrin increases the activity of dopamine and norepinephrine by inhibiting their reuptake in the brain, which helps improve mood and reduce cravings. Think of it as turning up the volume on neurotransmitters that promote motivation and focus. It does not act on serotonin, so it carries a different side-effect profile from many other antidepressants.

Why choose Wellbutrin?

• Generic availability makes it a cost-effective option compared with many brand-only agents.
• It has lower risk of sexual dysfunction and minimal weight gain, which are common concerns with other antidepressants.
• Off-label uses such as treating attention-deficit hyperactivity disorder exist, but they should only be considered after professional consultation.

Dosage, administration and lifestyle recommendations

Recommended dosage

• 150 mg once daily for the first three days, then increase to 300 mg once daily.
• Maximum daily dose: 450 mg (divided as 150 mg in the morning and 300 mg in the evening).

How to take

• Swallow the tablet whole with a full glass of water.
• Take it in the morning to reduce the chance of Insomnia.
• Food does not significantly affect absorption, but a consistent routine helps.

Missed dose

• If you remember the dose within 12 hours, take it promptly.
• If it is later than 12 hours, skip the missed dose and continue with the regular schedule.

Overdose

• Seek immediate medical attention.
• Symptoms may include rapid heart rate, seizures, or severe Agitation.

Special populations

• Elderly: Start at the lower dose (150 mg) and monitor for dizziness.
• Renal impairment: Dose may need reduction; consult a health professional.
• Pregnancy & breastfeeding: Use only if the benefit outweighs the risk.

Lifestyle & diet

• Avoid excessive alcohol as it increases seizure risk.
• Grapefruit juice may raise bupropion levels; limit intake.
• Maintain a regular sleep schedule to lessen insomnia.

Precautions and warnings

• Do not use if you have a history of seizures, eating disorders, or head trauma.
• Monitor for increased blood pressure; report persistent hypertension.
• Sudden mood changes or suicidal thoughts require immediate professional evaluation.

Drug interactions

Potential side effects

Common side effects

• Insomnia
• Dry mouth
• Headache

Less common side effects

• Tremor
• Weight loss
• Skin rash

Serious side effects

• Seizures (seek emergency care)
• Severe allergic reaction (hives, swelling, difficulty breathing)
• Persistent High Blood Pressure (consult a health professional)

Contraindications

• Seizure disorders
• Current or past eating disorders (Bulimia, Anorexia)
• Alcohol or sedative dependence
• Concurrent MAOI therapy

Storage

• Keep at 15 °C-30 °C (room temperature).
• Store in a dry place, away from direct sunlight.
• Keep out of reach of children and pets.

Wellbutrin alternatives

Frequently asked questions

How long does it take to feel the effect?

Most people notice an improvement in mood within 2-4 weeks, though full benefits may take up to 8 weeks.

Can I drink coffee while taking Wellbutrin?

Yes, modest coffee intake is fine, but excessive caffeine can worsen insomnia.

Is it safe to use Wellbutrin with antihypertensive medication?

Generally safe, but blood pressure should be monitored, especially during dose adjustments.

What should I do if I experience a seizure?

Seek emergency medical care immediately and inform the attending staff that you are on bupropion.

Can Wellbutrin cause weight loss?

Weight loss is reported in some users, but it is not guaranteed and should not be the primary reason for use.

Does Wellbutrin affect sexual function?

It has a lower incidence of sexual side effects compared with many SSRIs, but individual responses vary.

Is it OK to stop Wellbutrin abruptly?

Discontinuation should be tapered under medical guidance to reduce the risk of withdrawal symptoms.

Can I take Wellbutrin if I have high blood pressure?

Proceed with caution; blood pressure should be regularly monitored, and dosage may need adjustment.

Glossary

• Atypical antidepressant: A class of mood-lifting drugs that work differently from classic SSRIs.
• Reuptake inhibition: Blocking the reabsorption of neurotransmitters, leaving more available for brain activity.
• Seizure threshold: The level of electrical activity needed to trigger a seizure; certain drugs can lower this threshold.

Disclaimer

The information provided here is for general educational purposes only and does not replace professional medical advice. Off-label uses should only be considered after consulting a qualified health professional. Our service offers guidance on medication selection and usage but does not dispense prescriptions. Always discuss any concerns or questions with a qualified practitioner before starting or changing any medication.