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Fluticasone Propionate

Three fluticasone propionate products sit on this shelf: Advair Diskus for Asthma and COPD, Flonase Nasal Spray for Allergic Rhinitis, and Dymista, a combination nasal spray.

Advair Diskus

Asthma, Chronic Obstructive Pulmonary Disease

100mcg + 50mcg · 250mcg + 50mcg · 500mcg + 50mcg

Fluticasone and salmeterol inhalation powder for asthma and COPD. It combines a corticosteroid with a long-acting bronchodilator in one device.

From$21.00/ inhalerView

Flonase Nasal Spray

Allergic Rhinitis

50mcg

Fluticasone nasal spray for hay fever and allergies. It reduces inflammation in the nose, taking down swelling and congestion.

From$27.00/ sprayView

Dymista

Allergic Rhinitis

137mcg + 50mcg

Azelastine and fluticasone nasal spray for allergic rhinitis. It combines an antihistamine with a steroid to tackle both congestion and inflammation.

From$41.67/ sprayView

Key points

  • Advair Diskus pairs fluticasone propionate with salmeterol, a long-acting bronchodilator, in three strengths (100, 250 and 500 mcg); Dymista pairs it with azelastine, an antihistamine, in a single spray.
  • Fluticasone propionate is broken down by the CYP3A4 enzyme, so taking strong CYP3A4 inhibitors such as ritonavir, itraconazole or clarithromycin alongside it is not recommended, because increased systemic corticosteroid effects may occur.
  • Chickenpox and measles can take a more serious or even fatal course in susceptible children or adults using corticosteroids; avoid exposure if you have not had these diseases or been properly immunised.

How does Fluticasone Propionate work?

Fluticasone propionate is a synthetic corticosteroid that calms inflammation where it is delivered. Given by inhalation, it acts on the airways, reducing the swelling and mucus that trigger asthma symptoms and flare-ups, with fewer whole-body side effects than a corticosteroid tablet.

For the nasal spray, the label states that the precise mechanism by which fluticasone propionate affects rhinitis symptoms is not known, though it reduces the inflammatory response in the nasal lining. An inhaled dose reaches the bloodstream at about 5 to 11% of the amount delivered, depending on the device used, which is why local action dominates over systemic effects.

Brands and forms in this catalogue

The form determines where the drug lands and what else travels with it. Advair Diskus is an inhalation powder you breathe into the lungs; Flonase and Dymista are metered nasal sprays that coat the nasal lining. A reader who knows the molecule by another name may recognise the fluticasone-salmeterol combination as Seretide in the UK, or the inhaled corticosteroid alone as Flovent. Flonase is the brand name attached to the single-ingredient 50 mcg nasal spray. Dymista, marketed by Meda Pharmaceuticals, is the only product here that adds a second active molecule to fluticasone propionate. All three fall within the Allergy Relief or respiratory categories depending on the product.

Further reading

What is fluticasone propionate used for?

Fluticasone propionate is used for allergic rhinitis and asthma, and, in combination with salmeterol, for chronic obstructive pulmonary disease.

What does fluticasone propionate do to inflammation?

Fluticasone propionate is a synthetic corticosteroid that calms inflammation where it is applied. In the airways it reduces the swelling and mucus that trigger asthma symptoms, and in the nose it reduces the inflammatory response in the nasal lining.

How long does fluticasone propionate take to work?

Fluticasone propionate nasal spray starts to work in 12 to 24 hours, and its effect lasts for 24 hours.

What are the side effects of fluticasone propionate?

For the nasal spray form, common side effects include nasal dryness, sneezing and headache. Other side effects can include nosebleeds, throat irritation and nasal burning. A serious side effect is nasal septal perforation, which requires immediate medical attention.

Can fluticasone propionate be taken with other medicines?

Fluticasone propionate is broken down by the CYP3A4 enzyme, so strong CYP3A4 inhibitors such as ritonavir, itraconazole or clarithromycin are not recommended alongside it because increased systemic corticosteroid effects may occur. Ask your doctor or pharmacist before combining medicines.

What fluticasone propionate products are available?

On Direct Meds, fluticasone propionate comes as Flonase Nasal Spray, Advair Diskus and Dymista. Compare their forms, strengths and packs.

How is fluticasone propionate priced?

Compare the rand prices for each product, strength and pack above. Prices are converted from US dollars.

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Do I need a prescription for fluticasone propionate in South Africa?

No, not online. Direct Meds does not ask for a prescription to order fluticasone propionate. We are a broker, not a dispensing pharmacy. We arrange orders and delivery with our affiliated supplier on your behalf.

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Can I buy fluticasone propionate online in South Africa?

Yes. Our affiliated supplier delivers across South Africa. Estimated delivery is 7 days with Express Delivery, which includes online tracking, or up to 3 weeks with Regular Delivery.

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