Leflunomide
Leflunomide (Arava) is the one product here, a disease-modifying antirheumatic drug in 10 mg and 20 mg tablets used to slow joint damage in rheumatoid arthritis.
Key points
- Leflunomide is a non-biological DMARD that limits the growth of immune cells attacking the joints, slowing disease progression rather than masking pain.
- The active metabolite has a two-week half-life, so side effects may begin or continue even after the last dose.
- Leflunomide carries a boxed warning for birth defects: it must not be taken during pregnancy, and effective birth control is required for two years after stopping.
How does Leflunomide work?
Leflunomide converts in the body to an active metabolite called teriflunomide, which blocks an enzyme the immune system needs to produce new cells. By limiting the growth of activated immune cells, it reduces the inflammation that damages joints in rheumatoid arthritis, a condition managed under Autoimmune Support. The metabolite has a two-week half-life, so leflunomide’s effects, including side effects, may linger for weeks after the last dose.