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Linagliptin

Linagliptin is listed as Tradjenta, and in combination as Glyxambi (with empagliflozin) and Jentadueto XR (with extended-release metformin). All are tablets for Type 2 Diabetes Mellitus.

Medicines containing Linagliptin

Tradjenta

Type 2 Diabetes Mellitus

10mg

Linagliptin tablets for type 2 diabetes. It helps the body release more insulin when blood sugar is high.

From$2.19/ tabletView

Glyxambi

Type 2 Diabetes Mellitus

10mg + 5mg

Empagliflozin and linagliptin tablets for type 2 diabetes. Empagliflozin removes sugar in urine, linagliptin boosts insulin after meals.

From$3.04/ tabletView

Jentadueto XR

Type 2 Diabetes Mellitus

5mg + 1000mg

A linagliptin and metformin tablet for type 2 diabetes. Metformin cuts liver glucose output; linagliptin boosts insulin release after meals.

From$1.90/ tabletView

Key points

  • Linagliptin blocks DPP-4, the enzyme that breaks down the gut hormones that raise insulin after a meal, so insulin rises only when blood sugar is high.
  • It leaves the body mainly through bile rather than urine, so the dose does not change with kidney impairment.
  • Used alone it rarely causes low blood sugar; the risk rises when it is combined with a sulfonylurea or insulin.

Side effects to know

A blocked or runny nose and sore throat are the most common. Rarely it can inflame the pancreas: severe, persistent stomach pain that may spread to the back needs urgent care. Joint pain and blistering skin (bullous pemphigoid) have also been reported.

Further reading

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