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Prucalopride

Prucalopride, sold as Motegrity, is used to treat Chronic Idiopathic Constipation in adults. Motegrity is the only prucalopride product listed, in 1 mg and 2 mg tablets.

Medicine containing Prucalopride

Motegrity

Chronic Idiopathic Constipation

1mg · 2mg

Prucalopride tablets for chronic constipation. It stimulates the bowel's own nerves to get things moving again.

From$1.82/ tabletView

Key points

  • Prucalopride is a selective 5-HT4 receptor agonist that stimulates colonic peristalsis to increase bowel motility.
  • Suicides, suicide attempts, and suicidal ideation have been reported in clinical trials; a causal link to prucalopride has not been established, but patients should stop the medicine and contact their provider if depression worsens or suicidal thoughts emerge.
  • A history of hypersensitivity to prucalopride is a contraindication; reactions including rash, urticaria, and facial swelling have been observed.

How does Prucalopride work?

At therapeutic doses, prucalopride is selective for its target receptor and does not activate the other serotonin or gut-hormone receptors. More than 90% of an oral dose reaches the bloodstream, and the kidneys clear most of it, so the label warns against use in end-stage renal disease requiring dialysis and notes that a lower dose is needed in severe kidney impairment.

Further reading

FAQ

In which products can I find prucalopride?

On Direct Meds, prucalopride comes as Motegrity. Compare their forms, strengths and packs.

How is prucalopride priced?

Compare the price of each product, strength and pack above. Prices are set in US dollars and converted. Larger packs usually cost less per tablet.

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Is prucalopride available over the counter in South Africa?

Yes, online. Direct Meds does not ask for a prescription to order prucalopride. We are a broker, not a dispensing pharmacy. We arrange orders and delivery with our affiliated supplier on your behalf.

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Can I buy prucalopride online in South Africa?

Yes. Our affiliated supplier delivers across South Africa. Estimated delivery is 7 days with Express Delivery, which includes online tracking, or up to 3 weeks with Regular Delivery.

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