Sacubitril
Entresto is the only sacubitril product listed here, pairing 24 mg sacubitril with 26 mg valsartan in a single tablet to treat Heart Failure.
Medicine containing Sacubitril
Key points
- The combination lowers the risk of death and hospitalization in adults with certain types of heart failure, used alongside other medications.
- Do not take Entresto during pregnancy: the combination may cause death or serious injury to the fetus in the last six months.
- Entresto is also used to treat certain types of heart failure in children aged 1 year and older.
How does sacubitril work?
Sacubitril blocks an enzyme called neprilysin, which breaks down signalling molecules that regulate blood volume and vessel width. With neprilysin inhibited, those molecules stay active longer, easing the workload on a heart that cannot pump efficiently. Valsartan adds a second action: it blocks a natural substance that tightens blood vessels, so blood flows more smoothly. The two ingredients work in parallel to reduce the strain a failing heart carries.
Further reading
FAQ
In which products can I find sacubitril?
On Direct Meds, sacubitril comes as Entresto. Compare their forms, strengths and packs.
How much does sacubitril cost in South Africa?
Compare the price of each product, strength and pack above. Prices are set in US dollars and converted. Larger packs usually cost less per tablet.
Payment and prices →Is sacubitril available over the counter in South Africa?
Yes, online. Direct Meds does not ask for a prescription to order sacubitril. We are a broker, not a dispensing pharmacy. We arrange orders and delivery with our affiliated supplier on your behalf.
Ordering without a prescription →Can I buy sacubitril online in South Africa?
Yes. Our affiliated supplier delivers across South Africa. Estimated delivery is 7 days with Express Delivery, which includes online tracking, or up to 3 weeks with Regular Delivery.
How ordering works →Last updated