Entresto

Sacubitril and valsartan tablets for heart failure. They combine two actions to reduce strain on a failing heart.

Dosage

Pack size

Entresto is the reference name. You receive a generic with the same active ingredient and strength.

Supply requirements for Entresto depend on the medicine and destination. The fulfilment partner must confirm them before accepting an order.

Entresto details

Condition: Heart Failure
Alternative names: sacubitril, valsartan
Therapeutic class: Neprilysin Inhibitor, Angiotensin II Receptor Antagonist Combination
Pharmacological class: Angiotensin Receptor-Neprilysin Inhibitor (ARNI)
Contraindications: history of angioedema; concurrent use of ACE inhibitors; pregnancy
Minor side effects: dizziness; cough; headache
Moderate side effects: hyperkalaemia; hypotension; renal impairment
Serious side effects: angioedema, requires immediate medical attention
Dosage forms: Tablet
Administration route: Oral use
Supply category: Prescription-only medicine (POM)
Originator: Novartis
Onset Time: 1–2 hours
Duration: 12 hours
Storage instructions: Store below 25°C.
Drug interactions: ACE Inhibitors; Lithium; Potassium Supplements
Age restrictions: Approved for paediatric and adult patients.

Patient summary

Sacubitril and valsartan tablets for heart failure. They combine two actions to reduce strain on a failing heart.

Mechanism of action

Sacubitril blocks neprilysin to raise vasoprotective peptides while valsartan blocks vasoconstricting AT1 receptors.

Pregnancy and breastfeeding

Pregnancy: High risk of fetal toxicity and death. Contraindicated in pregnancy. Breastfeeding: Not recommended.

Entresto names the medicine you are looking for. What ships is a generic version of it.

A generic containing Sacubitril / Valsartan at the strength you pick.
Which generic brand and maker ships depends on stock and destination.
Check the active ingredient, strength, form, pack, seal, batch and expiry when it arrives.