Semaglutide
Semaglutide, sold as Rybelsus, is a GLP-1 receptor agonist tablet used for Type 2 Diabetes Mellitus, in 3 mg, 7 mg and 14 mg strengths.
Key points
- Acute pancreatitis has been reported with GLP-1 receptor agonists, including necrotising cases and fatal outcomes.
- The symptom to watch for is persistent, severe abdominal pain.
- Semaglutide has not been studied in people with a history of pancreatitis and should be used with caution in those cases.
How does semaglutide work?
Semaglutide mimics GLP-1, a hormone your gut releases after eating. It increases insulin release when blood sugar is high, reduces the sugar your liver sends into the bloodstream, and slows how quickly the stomach empties. Together these effects lower blood sugar after meals and between them, which is why it sits in the Diabetes Management category.
Further reading
What is semaglutide used for?
Semaglutide is used for type 2 diabetes mellitus. It is a GLP-1 receptor agonist.
How does semaglutide lower blood sugar?
Semaglutide mimics GLP-1, a hormone your gut releases after eating. It increases insulin release when blood sugar is high, reduces the sugar your liver sends into the bloodstream, and slows how quickly the stomach empties. Together these effects lower blood sugar after meals and between meals.
How long does semaglutide take to work?
Semaglutide usually takes 2 to 4 weeks to show its full effect.
What are the side effects of semaglutide?
Semaglutide can cause nausea, vomiting and diarrhoea, as well as abdominal pain, decreased appetite and constipation. More serious side effects include acute pancreatitis, anaphylaxis and acute kidney injury, which need immediate medical attention. Speak to your doctor or pharmacist if you are concerned.
Who should not take semaglutide?
Semaglutide is contraindicated in people with a history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, or diabetic ketoacidosis. It has not been studied in people with a history of pancreatitis and should be used with caution in those cases. Speak to your doctor or pharmacist for advice.
Which semaglutide products does Direct Meds sell?
On Direct Meds, semaglutide comes as Rybelsus. Compare their forms, strengths and packs.
What brand names is semaglutide sold under?
Semaglutide is also sold under brand names such as Ozempic and Wegovy. Names differ from country to country, so the active ingredient is the surest way to compare products.
How much does semaglutide cost in South Africa?
Compare the rand prices for each product, strength and pack above. Prices are converted from US dollars. Larger packs usually cost less per tablet.
Payment and prices →Can I buy semaglutide over the counter in South Africa?
Yes, online. Direct Meds does not ask for a prescription to order semaglutide. We are a broker, not a dispensing pharmacy. We arrange orders and delivery with our affiliated supplier on your behalf.
Ordering without a prescription →Can I buy semaglutide online in South Africa?
Yes. Our affiliated supplier delivers across South Africa. Estimated delivery is 7 days with Express Delivery, which includes online tracking, or up to 3 weeks with Regular Delivery.
How ordering works →Related articles
22 Sept 2026 ⋅ 4 min read
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