Aubagio
Teriflunomide tablets for relapsing remitting multiple sclerosis. It reduces the overactive immune response that damages nerve fibres in the brain and spinal cord.
- Category
- Neurology
- Active ingredient
- Teriflunomide
- Route
- Oral use
- Form
- Tablet; Film-coated tablet
- Strengths
- 14mg
Aubagio is the reference name. You receive a generic with the same active ingredient and strength.
No prescription needed: we place your order for Aubagio on your behalf.
- Conditions
- Relapsing Remitting Multiple Sclerosis · Clinically Isolated Syndrome · Active Secondary Progressive Multiple Sclerosis
- Therapeutic class
- Selective immunosuppressants
- Pharmacological class
- Pyrimidine synthesis inhibitor; Dihydroorotate dehydrogenase inhibitor
- Dosage forms
- Tablet; Film-coated tablet
- Administration route
- Oral use
- Originator
- Sanofi
- Storage instructions
- Store below 25°C. Keep in the original package to protect from moisture.
Contraindications
severe hepatic impairment; pregnancy; females of reproductive potential not using effective contraception; hypersensitivity to teriflunomide, leflunomide or any excipient; severe immunodeficiency states; significantly impaired bone marrow function; serious active infection; severe hypoproteinaemia; co-administration with leflunomide
Precautions and warnings
hepatotoxicity requiring monitoring of transaminase and bilirubin levels; bone marrow effects and immunosuppression potential; risk of serious infections; hypersensitivity reactions including anaphylaxis and serious skin reactions; peripheral neuropathy; increased blood pressure; respiratory effects including interstitial lung disease; tuberculosis screening prior to treatment; full blood count monitoring; accelerated elimination procedure with colestyramine or activated charcoal available
Minor side effects
headache; diarrhoea; nausea; alanine aminotransferase increased; alopecia; paraesthesia; fatigue; influenza
Moderate side effects
hepatitis; severe liver injury; pancreatitis; interstitial lung disease; peripheral neuropathy; severe infections; neutropenia; lymphopenia; leukopenia; thrombocytopenia; stevens-Johnson syndrome; toxic epidermal necrolysis; drug reaction with eosinophilia and systemic symptoms; hypertension; angioedema; anaphylaxis
Serious side effects
acute liver failure, requires immediate medical attention; stevens-Johnson syndrome, requires immediate medical attention; toxic epidermal necrolysis, requires immediate medical attention; anaphylaxis, requires immediate medical attention; serious infection, requires immediate medical attention; pancreatitis, requires immediate medical attention; interstitial lung disease, requires immediate medical attention
Patient summary
Teriflunomide tablets for relapsing remitting multiple sclerosis. It reduces the overactive immune response that damages nerve fibres in the brain and spinal cord.
Mechanism of action
Aubagio contains teriflunomide, an immunomodulatory medicine that selectively and reversibly inhibits the mitochondrial enzyme dihydroorotate dehydrogenase. This enzyme is needed by rapidly dividing cells, including activated lymphocytes that drive the immune attack on myelin in multiple sclerosis. By reducing the proliferation of these activated immune cells, Aubagio helps decrease inflammation and damage to the protective covering of nerves, thereby reducing the number of relapses and slowing the progression of disability.
Drug interactions
leflunomide; immunosuppressive agents; immunomodulating therapies; hepatotoxic drugs; warfarin; oral contraceptives; colestyramine; activated charcoal; repaglinide; pioglitazone; rosuvastatin; methotrexate; live vaccines; rifampicin; St John's wort
Age restrictions
Approved for adults aged 18 years and over and paediatric patients aged 10 years and older (EU). Safety and efficacy in children under 10 years not established.
Pregnancy and breastfeeding
Pregnancy: Aubagio is contraindicated in pregnancy. Teriflunomide caused teratogenicity and embryolethality in animal studies at exposures lower than human therapeutic levels. Pregnancy must be excluded before starting treatment. Females of reproductive potential must use effective contraception during treatment and after discontinuation until plasma teriflunomide levels are below a specified threshold. If pregnancy occurs, an accelerated elimination procedure with colestyramine or activated charcoal should be initiated to rapidly lower plasma levels. Breastfeeding: Contraindicated during treatment with teriflunomide.
FAQ
Is the Aubagio on Direct Meds a generic?
Yes, you receive a generic. Aubagio is the original brand, made by Sanofi, and Direct Meds uses the name to identify the medicine; the generic has the same active ingredient (teriflunomide) at the same strength. The generic brand and manufacturer depend on available stock.
How is Aubagio priced?
The price varies with pack size. Aubagio comes in a 14mg strength, in packs of 1 to 3 tablets, and the price of every option is shown above. Prices are set in US dollars and converted. Larger packs cost less per tablet.
Payment and prices →What other names is Aubagio sold under?
In South Africa, teriflunomide is also sold under brand names such as Auberif.
What is Aubagio used for?
Aubagio contains teriflunomide, used for relapsing remitting multiple sclerosis, clinically isolated syndrome and active secondary progressive multiple sclerosis.
What side effects can Aubagio cause?
The common side effects of teriflunomide are headache, diarrhoea, nausea, alanine aminotransferase increased, alopecia and paraesthesia. Less common ones include hepatitis, severe liver injury, pancreatitis, interstitial lung disease, peripheral neuropathy and severe infections. Serious but less common side effects include acute liver failure, Stevens-Johnson syndrome, toxic epidermal necrolysis and anaphylaxis, which need urgent medical attention.
What does Aubagio interact with?
Teriflunomide can interact with leflunomide, immunosuppressive agents, immunomodulating therapies, hepatotoxic drugs, warfarin and oral contraceptives. Tell your doctor or pharmacist about every medicine you take before you start taking Aubagio.
Is Aubagio available over the counter in South Africa?
Online, yes: Direct Meds does not ask for a prescription to order Aubagio. We are a broker, not a dispensing pharmacy. We arrange orders and delivery with our affiliated supplier on your behalf.
Ordering without a prescription →Can I buy Aubagio online in South Africa?
Yes. Our affiliated supplier delivers across South Africa. Estimated delivery is 7 days with Express Delivery, which includes online tracking, or up to 3 weeks with Regular Delivery.
How ordering works →What you will receive
Aubagio names the medicine you are looking for. What ships is a generic version of it.
- A generic containing Teriflunomide at the strength you pick.
- Which generic brand and maker ships depends on stock and destination.
- Check the active ingredient, strength, form, pack, seal, batch and expiry when it arrives.