Differin
Adapalene cream for acne. It helps keep pores from getting blocked.
All strengths and pack prices
- Condition
- Acne Vulgaris
- Alternative names
- adapalene
- Therapeutic class
- Third-Generation Topical Retinoid
- Pharmacological class
- Retinoid
- Known off-label uses
- rosacea
- Contraindications
- hypersensitivity to adapalene; broken or eczematous skin
- Minor side effects
- skin dryness; erythema; skin scaling
- Moderate side effects
- burning sensation; pruritus; sun sensitivity
- Serious side effects
- severe localised angioedema, requires immediate medical attention
- Dosage forms
- Cream
- Administration route
- Cutaneous use
- Patient summary
- Adapalene cream for acne. It helps keep pores from getting blocked.
- Originator
- Galderma
- Onset time
- 2–4 weeks
- Duration
- 24 hours
- Storage instructions
- Store below 25°C.
- Drug interactions
- Benzoyl Peroxide; Salicylic Acid
- Age restrictions
- Approved for paediatric patients over twelve years and adults.
Mechanism of action
Binds selectively to nuclear retinoic acid receptors, regulating cell differentiation to prevent microcomedone formation in pores.
Pregnancy and breastfeeding
Pregnancy: Avoid during pregnancy as safety is unconfirmed. Breastfeeding: Confirm breastfeeding suitability with a qualified clinician or pharmacist before use.
FAQ
Is the Differin on Direct Meds a generic?
Yes, you receive a generic. Differin is the original brand, made by Galderma, and Direct Meds uses the name to identify the medicine; the generic has the same active ingredient (adapalene) at the same strength. The generic brand and manufacturer depend on available stock.
How is Differin priced?
The price varies with pack size. Differin comes as 0.1% 15g tubes, in packs of 2 to 10 tubes, and the price of every option is shown above. Prices are set in US dollars and converted. Larger packs cost less per tube.
Payment and prices →What is Differin used for?
Differin contains adapalene, used for acne vulgaris.
How quickly does Differin work?
Adapalene usually starts to work within 2 to 4 weeks. The exact timing differs between people.
Does Differin have side effects?
Yes. The common side effects of adapalene are skin dryness, redness (erythema) and skin scaling. Less common ones include burning sensation, itching (pruritus) and sun sensitivity. Serious but less common side effects include severe localised angioedema, which needs urgent medical attention.
What does Differin interact with?
Adapalene can interact with benzoyl peroxide and salicylic acid. Tell your doctor or pharmacist about every medicine you take before you start taking Differin.
Can I buy Differin over the counter in South Africa?
Online, yes: Direct Meds does not ask for a prescription to order Differin. We are a broker, not a dispensing pharmacy. We arrange orders and delivery with our affiliated supplier on your behalf.
Ordering without a prescription →Can I buy Differin online in South Africa?
Yes. Our affiliated supplier delivers across South Africa. Estimated delivery is 7 days with Express Delivery, which includes online tracking, or up to 3 weeks with Regular Delivery.
How ordering works →What you will receive
Differin names the medicine you are looking for. What ships is a generic version of it.
- A generic containing Adapalene at the strength you pick.
- Which generic brand and maker ships depends on stock and destination.
- Check the active ingredient, strength, form, pack, seal, batch and expiry when it arrives.