Hepcinat LP
Ledipasvir and sofosbuvir tablets for chronic hepatitis C. One of the newer direct-acting antiviral combinations, taken as a course to clear the virus.
All strengths and pack prices
| Strength | Pack | Price | Per unit |
|---|---|---|---|
| 90mg + 400mg | 28 tablets | $1360.00 | $48.57 |
| 90mg + 400mg | 56 tablets | $2644.00 | $47.21 |
- Category
- Hepatitis Treatment
- Active ingredients
- Ledipasvir · Sofosbuvir
- Route
- Oral use
- Form
- Film-coated tablet; Granules
- Strengths
- 90mg + 400mg
No prescription needed: we place your order for Hepcinat LP on your behalf.
- Condition
- Chronic Hepatitis C
- Alternative names
- Harvoni
- Pharmacological class
- HCV NS5A inhibitor; HCV NS5B nucleotide polymerase inhibitor
- Dosage forms
- Film-coated tablet; Granules
- Administration route
- Oral use
- Manufacturer
- Natco Pharma Limited
- Storage instructions
- Store below 30°C. Keep in the original container. Protect from light.
Therapeutic class
Direct-acting antiviral agents for hepatitis C; Antivirals for treatment of HCV infections
Contraindications
hypersensitivity to ledipasvir, sofosbuvir or any excipient; co-administration with rosuvastatin; co-administration with strong p-glycoprotein inducers including carbamazepine, phenobarbital, phenytoin, rifampicin, rifabutin and st. john's wort
Precautions and warnings
risk of hepatitis b virus reactivation in patients co-infected with hbv and hcv; severe symptomatic bradycardia when co-administered with amiodarone particularly in patients also receiving beta blockers or with underlying cardiac comorbidities; no dose recommendation for patients with severe renal impairment or end-stage renal disease; caution with concomitant use of moderate p-gp inducers such as oxcarbazepine; contains lactose and sunset yellow which may cause allergic reactions; ns5a resistance mutations may persist long-term and limit retreatment options in patients who fail therapy
Minor side effects
fatigue; headache; nausea; diarrhoea; insomnia; asthenia; rash; pruritus; irritability; myalgia; arthralgia; cough; dyspnoea; dizziness; decreased appetite; pyrexia; abdominal pain; constipation; back pain; muscle spasms
Moderate side effects
hepatitis b reactivation; severe bradycardia; angioedema; stevens-johnson syndrome; pancreatitis; acute kidney injury; hepatic decompensation; hepatic failure
Serious side effects
severe symptomatic bradycardia, requires immediate medical attention; signs of hepatitis b reactivation including jaundice, dark urine, abdominal pain, requires immediate medical attention; angioedema with swelling of face, lips, tongue or throat, requires immediate medical attention; severe cutaneous reactions including widespread rash with blistering, requires immediate medical attention; signs of pancreatitis including severe upper abdominal pain radiating to the back, requires immediate medical attention; signs of hepatic decompensation including confusion, abdominal swelling, jaundice, requires immediate medical attention
Patient summary
Ledipasvir and sofosbuvir tablets for chronic hepatitis C. One of the newer direct-acting antiviral combinations, taken as a course to clear the virus.
Mechanism of action
Hepcinat LP contains ledipasvir and sofosbuvir. Ledipasvir blocks the hepatitis C virus NS5A protein needed for viral RNA replication. Sofosbuvir is a nucleotide prodrug that converts to its active form inside liver cells and acts as a chain terminator, stopping the virus from copying its genetic material. Together, these medicines prevent the hepatitis C virus from multiplying and allow the body to clear the infection.
Drug interactions
amiodarone; rifampicin; rifabutin; carbamazepine; phenobarbital; phenytoin; st. john's wort; oxcarbazepine; rosuvastatin; pravastatin; atorvastatin; digoxin; dabigatran; tenofovir disoproxil fumarate; antacids; h2 receptor antagonists; proton pump inhibitors; rifapentine; tipranavir; ritonavir; simeprevir
Age restrictions
Not recommended in paediatric patients below 3 years of age. Safety and efficacy not established.
Pregnancy and breastfeeding
Pregnancy: No adequate and well-controlled studies in pregnant women. As a precautionary measure, it is preferable to avoid use during pregnancy. Fertile women must use effective contraception during treatment. Breastfeeding: Confirm breastfeeding suitability with a qualified clinician or pharmacist before use.
FAQ
What will I receive when I order Hepcinat LP?
A branded generic or generic containing ledipasvir and sofosbuvir, at the same strength. Direct Meds lists the medicine as Hepcinat LP; the exact brand and manufacturer depend on stock. The combination is a direct-acting antiviral agents for hepatitis c, used for chronic hepatitis C.
How much does Hepcinat LP cost in South Africa?
The price varies with pack size. Hepcinat LP comes in a 90mg + 400mg strength, in packs of 28 to 56 tablets, and the price of every option is shown above. Prices are set in US dollars and converted. Larger packs cost less per tablet.
Payment and prices →Is Hepcinat LP sold under other names?
Other brand names for ledipasvir and sofosbuvir include Harvoni.
What is Hepcinat LP used for?
Hepcinat LP contains ledipasvir and sofosbuvir, used for chronic hepatitis C.
What are the side effects of Hepcinat LP?
The common side effects of ledipasvir and sofosbuvir are fatigue, headache, nausea, diarrhoea, insomnia and asthenia. Less common ones include hepatitis b reactivation, severe bradycardia, angioedema, Stevens-Johnson syndrome, pancreatitis and acute kidney injury. Serious but less common side effects include severe symptomatic bradycardia, signs of hepatitis b reactivation including jaundice, dark urine, abdominal pain, angioedema with swelling of face, lips, tongue or throat and severe cutaneous reactions including widespread rash with blistering, which need urgent medical attention.
What does Hepcinat LP interact with?
Ledipasvir and sofosbuvir can interact with amiodarone, rifampicin, rifabutin, carbamazepine, phenobarbital and phenytoin. Tell your doctor or pharmacist about every medicine you take before you start taking Hepcinat LP.
Is Hepcinat LP available over the counter in South Africa?
Online, yes: Direct Meds does not ask for a prescription to order Hepcinat LP. We are a broker, not a dispensing pharmacy. We arrange orders and delivery with our affiliated supplier on your behalf.
Ordering without a prescription →Where can I buy Hepcinat LP in South Africa?
On Direct Meds: choose the strength and pack, then check out. Our affiliated supplier delivers across South Africa. Estimated delivery is 7 days with Express Delivery, which includes online tracking, or up to 3 weeks with Regular Delivery.
How ordering works →