Cabergoline
Cabergoline (Dostinex) is a dopamine agonist that lowers prolactin levels in hyperprolactinaemia. The single tablet product listed here comes in 0.25 mg and 0.5 mg strengths.
Key points
- Cabergoline acts mainly through dopamine D2 receptors on the pituitary gland.
- Dostinex is the original brand of cabergoline, marketed by Pfizer.
How does Cabergoline work?
Cabergoline binds to dopamine D2 receptors on the prolactin-producing cells of the pituitary gland. By mimicking dopamine, the body’s natural signal that keeps prolactin in check, it tells those cells to reduce secretion. The prolactin-lowering effect lasts well beyond a single dose because cabergoline stays bound to the receptors for an extended period, which is why it is described as long-acting.
For someone with Hyperprolactinaemia, the medicine works at the source, quieting the cells that drive the excess. Dostinex is listed under Hormone Therapy on this shelf.
Further reading
What is cabergoline used for?
Cabergoline is used for hyperprolactinaemia. It works by lowering prolactin levels.
How long does cabergoline take to work?
Cabergoline usually takes 2 to 4 weeks to show its full effect.
What are the side effects of cabergoline?
Common side effects include nausea, headache and dizziness. Other side effects can include fatigue, constipation and postural hypotension. Serious side effects include cardiac valvulopathy and psychotic episodes, each of which requires immediate medical attention.
Can cabergoline be taken with other medicines?
Cabergoline may interact with metoclopramide, phenothiazines and antihypertensives. If you take any of these, speak to your doctor or pharmacist.
Who should not take cabergoline?
Cabergoline is contraindicated in people with uncontrolled hypertension, a history of cardiac valvular disorders, or hepatic impairment. Speak to your doctor or pharmacist if this applies to you.
Which cabergoline products does Direct Meds sell?
On Direct Meds, cabergoline comes as Dostinex. Compare their forms, strengths and packs.
How much does cabergoline cost in South Africa?
Compare the rand prices for each product, strength and pack above. Prices are converted from US dollars. Larger packs usually cost less per tablet.
Payment and prices →Can I buy cabergoline over the counter in South Africa?
Yes, online. Direct Meds does not ask for a prescription to order cabergoline. We are a broker, not a dispensing pharmacy. We arrange orders and delivery with our affiliated supplier on your behalf.
Ordering without a prescription →Can I buy cabergoline online in South Africa?
Yes. Our affiliated supplier delivers across South Africa. Estimated delivery is 7 days with Express Delivery, which includes online tracking, or up to 3 weeks with Regular Delivery.
How ordering works →Related articles
22 Sept 2026 ⋅ 4 min read
Cabergoline and Dostinex: when high prolactin needs treatment
A high prolactin result does not always mean a tumour. Learn when cabergoline helps, why the cause matters, and which monitoring and side effects to discuss.
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