Naltrexone

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naltrexone

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Naltrexone is an opioid antagonist medication used primarily in addiction management programs to reduce cravings and block the euphoric effects associated with alcohol or opioid use. It functions by binding to opioid receptors, preventing exogenous opioids from exerting their effects on the central nervous system. This medication supports recovery efforts for eligible adults undergoing treatment for substance dependence issues. Naltrexone 50mg tablets are stocked and available for discrete, tracked delivery to all locations within South Africa.

Table of contents

Naltrexone (Naltrexone Hydrochloride) Buyer and Patient Handbook in South Africa

What is Naltrexone?

Naltrexone is an opioid-receptor antagonist pill used to support recovery from alcohol-related problems and to reduce cravings in people who have stopped using opioids. It belongs to the class of medication-assisted treatments for substance-use disorders and is approved by the FDA, EMA and South Africa’s SAHPRA. The tablets are supplied in a 50 mg strength.

Who Should Use Naltrexone?

  • Adults who have completed detox from opioids and want to prevent relapse.
  • Individuals seeking to lessen alcohol cravings as part of a comprehensive recovery plan.
  • People who are motivated to engage in counseling or support groups alongside medication.

How Does It Work?

Naltrexone blocks the mu-opioid receptors in the brain, so the rewarding feelings from alcohol or opioids are dramatically reduced. Think of it as putting a lock on the “pleasure” switch that these substances normally turn on. Because it does not produce a high, the risk of abuse is very low, but it should never be taken while opioids are still active in the body.

Why Choose Naltrexone?

  • Proven efficacy: Clinical trials show it cuts heavy-drinking days by about 30 % and lowers opioid relapse rates.
  • Convenient dosing: Once-daily 50 mg tablets simplify adherence.
  • Generic availability: The generic form offers the same therapeutic effect at a lower cost compared with brand-only options. Off-label uses, such as for certain autoimmune conditions, should be discussed with a qualified health professional.

Dosage, Administration, Lifestyle and Dietary Recommendations

  • 50 mg tablet taken once daily, preferably in the morning.

How to Take

  1. Swallow the whole tablet with a full glass of water.
  2. Take it with or without food-consistent timing helps maintain steady blood levels.

Missed Dose

  • If you miss a dose and it is less than 12 hours later, take it as soon as you remember.
  • Skip it if it is almost time for the next dose; do not double-dose.

Overdose

  • Call emergency services (dial 10177 in South Africa) and inform them of a possible Naltrexone overdose.
  • Bring the medication package for reference.

Special Populations

  • Elderly: Start with the standard 50 mg dose; monitor for dizziness.
  • Pregnancy & breastfeeding: Use only if the benefit outweighs the risk; discuss with a health professional.
  • Kidney or liver impairment: Dose adjustment may be required; professional assessment is essential.

Lifestyle & Diet

  • Avoid taking Naltrexone within 7-10 days of an opioid-containing medication.
  • Grapefruit juice does not significantly affect Naltrexone but maintain a balanced diet.
  • Alcohol consumption should be reduced; Naltrexone works best with moderate or no drinking.

Precautions and Warnings

  • Do not start Naltrexone if you are currently using opioids; an opioid-withdrawal reaction can be severe.
  • Report any persistent nausea, vomiting, or severe headache to a health professional promptly.
  • Use caution when driving or operating machinery until you know how the medication affects you.

Drug Interactions

Drug Class Risk Action
Opioid analgesics May precipitate withdrawal Discontinue opioids ≥ 7 days before starting
Benzodiazepines Increased sedation Monitor closely, adjust dose if needed
Hepatotoxic drugs Potential liver strain Check liver function regularly

Potential Side Effects

Common Side Effects

  • Nausea
  • Headache
  • Fatigue
  • Dizziness

Less Common Side Effects

Serious Side Effects

  • Severe liver injury (yellowing of skin/eyes) - seek urgent medical care
  • Unexpected allergic reaction (rash, swelling, difficulty breathing) - call emergency services

Who Should Avoid This Medication?

  • Individuals actively using opioid pain relievers or heroin.
  • Patients with severe hepatic failure.
  • Anyone with a known hypersensitivity to Naltrexone or its excipients.

Storage Instructions

  • Keep tablets in the original container, tightly closed.
  • Store at room temperature (15-30 °C) away from direct sunlight.
  • Keep out of reach of children and pets.

Naltrexone Alternatives

Name Class Key Difference
Acamprosate Glutamate modulator Works on brain chemistry rather than opioid receptors
Disulfiram Aldehyde dehydrogenase inhibitor Causes unpleasant reaction if alcohol is consumed
Naloxone (injectable) Opioid antagonist Short-acting, used for emergency overdose reversal

Frequently Asked Questions

How long does it take for Naltrexone to start working?

Most people notice a reduction in cravings within 3-5 days of daily use.

Can I drink alcohol while taking Naltrexone?

The medication lessens the rewarding effects of alcohol, so occasional light drinking may be tolerated, but heavy drinking defeats its purpose and should be avoided.

Will Naltrexone affect my libido?

Some users report a temporary dip in sexual desire, but this usually resolves after a few weeks.

Is it safe to combine Naltrexone with my antidepressant?

Generally yes, but discuss any potential interactions with your prescriber, especially with monoamine-oxidase inhibitors.

What should I do if I experience severe nausea?

Take the tablet with food and a full glass of water; if nausea persists for more than 48 hours, contact a health professional.

Can I stop taking Naltrexone suddenly?

Yes, the drug does not cause physical dependence, but stopping abruptly may increase cravings; tapering is sometimes advised.

Does Naltrexone cause weight gain?

Weight changes are not a common side effect, but any significant change should be discussed with a health professional.

Is Naltrexone covered by private medical schemes in South Africa?

Coverage varies; check with your scheme provider for specific benefits.

Glossary

  • Opioid-receptor antagonist: A medication that blocks the brain receptors that opioids normally activate.
  • Craving: A strong desire or urge to use a substance.
  • Hepatotoxic: Having the potential to damage the liver.

Disclaimer

The information provided here is for general educational purposes and does not replace personalized medical advice. off-label uses are not endorsed; always consult a qualified health professional before starting or stopping any medication. Our service offers access to approved medicines through accredited South African pharmacies; we do not dispense prescriptions. Individual results may vary.

How to Purchase Naltrexone | Naltrexone Hydrochloride Through Our Online Pharmacy

Buying Naltrexone | Naltrexone Hydrochloride from our online pharmacy is simple and convenient. Start by selecting the desired dosage and quantity displayed on the product page. The price updates in real-time, so you know exactly what to expect before proceeding. Click the Add to Basket button to include your selection in your cart. You can continue browsing for additional medications or proceed directly to the checkout. On the Checkout Page, finalize your purchase using our secure payment system, ensuring your details remain confidential and protected.

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