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Tricor (Fenofibrate) Buyer and Patient Handbook in South Africa

What is Tricor?

Tricor is a fenofibrate-based medication classified as a lipid-control agent, used to lower High Cholesterol and triglyceride levels. It is approved by SAHPRA and is available as a solid oral pill. The drug is indicated for patients with dyslipidaemia, particularly when dietary measures and lifestyle changes are insufficient.

Who Should Use Tricor?

• Adults diagnosed with primary or secondary hyperlipidaemia
• Patients with high triglycerides (≥ 2.3 mmol/L)
• Individuals with mixed dyslipidaemia (elevated LDL-C and triglycerides)

How Does It Work?

Fenofibrate activates peroxisome proliferator-activated receptor-α (PPAR-α), a nuclear receptor that regulates genes involved in lipid metabolism. Activation increases the breakdown of triglyceride-rich particles and raises HDL-C, while modestly lowering LDL-C. The result is a healthier lipid profile that reduces the risk of atherosclerotic events. Abuse potential is negligible.

Why Choose Tricor?

• Brand confidence: Manufactured under strict GMP standards with proven bioavailability.
• Convenient dosing: Once-daily pill simplifies adherence.
• Clinical evidence: Large trials have demonstrated significant triglyceride reduction and modest LDL-C improvement.

Off-label use (e.g., for secondary Prevention of Cardiovascular Disease) should only be considered after professional consultation.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• 160 mg tablet once daily, or
• 200 mg tablet once daily, as prescribed.

How to Take

• Swallow the whole pill with a glass of water.
• Take with or without food; consistency with meals helps reduce gastrointestinal discomfort.

Missed Dose

• If you remember within 12 hours, take it now.
• If more than 12 hours have passed, skip the missed tablet and resume your regular schedule.

Overdose

• Seek immediate medical attention.
• Supportive care may include monitoring of vital signs and symptomatic treatment.

Special Populations

• Elderly: No dose adjustment required if renal function is normal.
• Renal impairment: Use the 160 mg dose; avoid if creatinine clearance < 30 mL/min.
• Pregnancy & lactation: Not recommended; discuss alternatives with a healthcare professional.

Lifestyle & Diet

• Maintain a heart-healthy diet low in saturated fats and refined carbohydrates.
• Avoid large amounts of grapefruit juice, which can increase fenofibrate concentrations.
• Regular exercise (150 min moderate aerobic activity per week) enhances lipid-lowering effects.

Precautions and Warnings

• Monitor liver enzymes and renal function before starting therapy and periodically thereafter.
• Use cautiously in patients with pre-existing liver disease or gallstones.
• Discontinue if severe muscle Pain or weakness develops; report promptly.

Drug Interactions

Potential Side Effects

Common Side Effects

• Headache
• Nausea or abdominal discomfort
• Mild muscle aches

Less Common Side Effects

• Elevated liver enzymes
• Diarrhoea
• Dizziness

Serious Side Effects

• Severe muscle breakdown (rhabdomyolysis) - stop drug and seek urgent care.
• Hepatitis or jaundice - discontinue and consult a clinician.

Who Should Avoid This Medication?

• Known hypersensitivity to fenofibrate or any excipients
• Severe hepatic impairment (Child-Pugh C)
• End-stage renal disease (dialysis-dependent)

Storage Instructions

• Keep tablets in the original blister at 20-25 °C (room temperature).
• Protect from moisture and direct sunlight.
• Keep out of reach of children.

Tricor Alternatives

Frequently Asked Questions

How long does it take for Tricor to start working?

A measurable reduction in triglycerides is usually seen within 2 weeks, with maximal effect by 8 weeks.

Can I take Tricor with my cholesterol-lowering statin?

Yes, but the combination increases the risk of muscle toxicity; use the lowest effective statin dose and have CK monitored.

Does drinking alcohol affect Tricor?

Moderate alcohol intake does not interfere, but excess alcohol can raise triglycerides and counteract the drug’s benefits.

Is Tricor safe for people with diabetes?

Fenofibrate can modestly improve glycaemic control; however, monitor blood glucose as it may fluctuate.

What should I do if I experience muscle pain?

Stop the medication and contact a healthcare professional immediately; they may order a creatine kinase test.

Can I crush or split the tablet?

Do not crush or split; the film-coated tablet is designed for controlled release.

Will Tricor cause weight gain?

Weight change is uncommon; maintain a balanced diet and regular exercise.

Is Tricor available over the counter in South Africa?

No, it requires a prescription from a qualified prescriber.

Glossary

• Triglycerides: A type of fat in the blood; high levels increase cardiovascular risk.
• PPAR-α: A protein that controls genes involved in fat metabolism.
• Rhabdomyolysis: A serious condition where damaged muscle releases harmful substances into the bloodstream.

Disclaimer

This handbook provides general information about Tricor (fenofibrate) and is not a substitute for professional medical advice. Use of off-label indications should be discussed with a qualified healthcare provider. Our online pharmacy platform offers convenient access to approved medicines, but the ultimate responsibility for safe use lies with the patient. Always consult a doctor or pharmacist before starting or changing any medication.