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Tacrolimus

Two tacrolimus products sit on this shelf, split by route and purpose: Prograf tablets prevent organ transplant rejection, while Protopic’s 0.03% tube addresses atopic dermatitis.

Protopic

Atopic Dermatitis

0.03% 10gm

Tacrolimus ointment for atopic dermatitis. It calms the skin and helps clear redness and itching.

From$27.60/ tubeView

Prograf

Organ Transplant Rejection

0.5mg · 1mg · 5mg

Tacrolimus tablets to stop organ transplant rejection. It suppresses the immune system's attack on the new organ and requires regular blood level checks.

From$3.34/ tabletView

Key points

  • PROGRAF carries a boxed warning for serious infections and malignancies that may lead to hospitalisation or death.
  • Nephrotoxicity was reported in around 52% of kidney transplant patients treated with PROGRAF, due to its effect on the blood vessels of the kidney.
  • PROGRAF is not interchangeable with extended-release tacrolimus products; switching between the two requires physician supervision.

Two products, two jobs

Prograf (0.5 mg, 1 mg, 5 mg tablets) is the oral calcineurin inhibitor a transplant team prescribes to stop the immune system attacking a new kidney. Protopic (0.03% tube, listed under Skin Care) is a separate formulation for the skin. The safety data above, including the boxed warning and the nephrotoxicity figure, applies to the oral transplant product.

Further reading