Methotrexate Tablets
Methotrexate tablets for rheumatoid arthritis and psoriasis. It calms the immune system's attack on joints and skin.
- Category
- Oncology Support
- Active ingredient
- Methotrexate
- Route
- Oral use
- Form
- Tablet
- Strengths
- 2.5mg · 5mg · 7.5mg · 10mg
A generic with the stated active ingredient and strength. The maker is confirmed before dispatch.
No prescription needed: we place your order for Methotrexate Tablets on your behalf.
- Conditions
- Rheumatoid Arthritis · Psoriasis · Acute Lymphocytic Leukaemia
- Alternative names
- rheumatrex
- Therapeutic class
- Folate Analog Antimetabolite
- Pharmacological class
- Antineoplastic and Antirheumatic
- Known off-label uses
- ectopic pregnancy; crohn's disease
- Minor side effects
- nausea; mouth sores; fatigue
- Moderate side effects
- myelosuppression; elevated liver enzymes; alopecia
- Dosage forms
- Tablet
- Administration route
- Oral use
- Onset Time
- 3–6 weeks
- Duration
- 12–24 hours
- Storage instructions
- Store below 25°C.
- Drug interactions
- NSAIDs; Penicillin; Trimethoprim
- Age restrictions
- Approved for paediatric and adult populations.
Contraindications
pregnancy; severe renal impairment; severe bone marrow suppression; chronic liver disease
Serious side effects
severe hepatotoxicity, requires immediate medical attention; pulmonary fibrosis, requires immediate medical attention; severe pancytopenia, requires immediate medical attention
Patient summary
Methotrexate tablets for rheumatoid arthritis and psoriasis. It calms the immune system's attack on joints and skin.
Mechanism of action
Inhibits dihydrofolate reductase, preventing synthesis of tetrahydrofolate required for DNA synthesis inside cellular structures.
Pregnancy and breastfeeding
Pregnancy: Highly teratogenic and abortifacient. Highly contraindicated. Breastfeeding: Contraindicated.
Is Methotrexate a generic?
Yes. Methotrexate is a generic medicine sold under the name of its active ingredient, methotrexate, rather than under a brand. The exact manufacturer depends on stock.
How is Methotrexate priced?
Methotrexate comes in 2.5mg, 5mg, 7.5mg and 10mg strengths, in packs of 30 to 360 tablets, and the price of every option is shown above in rand, converted from US dollars. Larger packs cost less per tablet.
Payment and prices →What other names is Methotrexate sold under?
Other brand names for methotrexate include Rheumatrex.
What is Methotrexate used for?
Methotrexate is used for rheumatoid arthritis, psoriasis and acute lymphocytic leukaemia.
How long does Methotrexate take to work?
Methotrexate usually starts to work within 3 to 6 weeks. How quickly it works can differ from one person to another.
What are the side effects of Methotrexate?
The common side effects of methotrexate are nausea, mouth sores and fatigue. Less common ones include myelosuppression, elevated liver enzymes and alopecia. Serious but less common side effects include severe liver damage (hepatotoxicity), pulmonary fibrosis and severe pancytopenia, which need urgent medical attention.
Which medicines interact with Methotrexate?
Methotrexate can interact with NSAIDs, penicillin and trimethoprim. Tell your doctor or pharmacist about every medicine you take before you start taking Methotrexate.
Can I buy Methotrexate over the counter in South Africa?
Online, yes: Direct Meds does not ask for a prescription to order Methotrexate. We are a broker, not a dispensing pharmacy. We arrange orders and delivery with our affiliated supplier on your behalf.
Ordering without a prescription →Do you deliver Methotrexate to South Africa?
Yes. Our affiliated supplier delivers across South Africa. Estimated delivery is 7 days with Express Delivery, which includes online tracking, or up to 3 weeks with Regular Delivery.
How ordering works →What you will receive
Methotrexate Tablets is a generic, listed by its active ingredient, Methotrexate.
- The maker is confirmed before dispatch.
- Check the active ingredient, strength, form, pack, seal, batch and expiry details.