Xtandi
Enzalutamide capsules for prostate cancer. They block male hormones like testosterone from helping cancer grow.
All strengths and pack prices
| Strength | Pack | Price | Per unit |
|---|---|---|---|
| 40mg | 28 capsules | $571.00 | $20.39 |
| 40mg | 56 capsules | $1065.00 | $19.02 |
- Category
- Prostate Health
- Active ingredient
- Enzalutamide
- Route
- Oral use
- Form
- Capsule, soft; Film-coated tablet
- Strengths
- 40mg
Xtandi is the reference name. You receive a generic with the same active ingredient and strength.
No prescription needed: we place your order for Xtandi on your behalf.
- Condition
- Prostate Cancer
- Therapeutic class
- Hormone antagonists and related agents
- Pharmacological class
- Androgen receptor inhibitor
- Minor side effects
- fatigue; asthenia; hot flush; hypertension; falls; fracture
- Moderate side effects
- headache; dry skin; pruritus; muscle spasms; back pain; haematuria
- Dosage forms
- Capsule, soft; Film-coated tablet
- Administration route
- Oral use
- Originator
- Astellas Pharma Europe B.V.
- Storage instructions
- This medicinal product does not require any special storage conditions.
Contraindications
hypersensitivity to enzalutamide or any excipients; women who are or may become pregnant
Precautions and warnings
risk of seizure; consider discontinuation if seizure occurs; posterior reversible encephalopathy syndrome has been reported; discontinue if confirmed; concomitant use with strong CYP2C8 inhibitors should be avoided or enzalutamide dose should be reduced; caution with CYP3A4, CYP2C9 or CYP2C19 substrates with narrow therapeutic index; ischaemic heart disease has been reported; falls and fractures reported; risk factors such as osteoporosis should be assessed; hypertension has been reported; blood pressure should be monitored; not to be handled by women who are or may become pregnant
Serious side effects
seizure, requires immediate medical attention; posterior reversible encephalopathy syndrome, requires immediate medical attention; myocardial infarction, requires immediate medical attention; ischaemic heart disease, requires immediate medical attention; severe hypersensitivity reaction, requires immediate medical attention
Patient summary
Enzalutamide capsules for prostate cancer. They block male hormones like testosterone from helping cancer grow.
Mechanism of action
Xtandi contains enzalutamide, a medicine that blocks the action of male hormones called androgens, including testosterone. Prostate cancer cells need androgens to grow. Enzalutamide works at multiple steps in the androgen receptor signalling pathway by preventing androgens from attaching to their receptors on cancer cells and blocking the receptors from sending growth signals to the cell nucleus. This helps slow the growth of prostate cancer and delay the spread of the disease.
Drug interactions
strong CYP2C8 inhibitors; CYP3A4 inducers; CYP3A4 substrates with narrow therapeutic index; CYP2C9 substrates with narrow therapeutic index; CYP2C19 substrates with narrow therapeutic index; warfarin; clopidogrel
Age restrictions
Not for use in children and adolescents. Safety and efficacy have not been established in paediatric population.
Pregnancy and breastfeeding
Pregnancy: Contraindicated in women who are or may become pregnant. Not indicated for use in women. May cause harm to the unborn child. Effective contraception required for male patients with female partners of childbearing potential. Breastfeeding: Confirm breastfeeding suitability with a qualified clinician or pharmacist before use.
FAQ
Is the Xtandi on Direct Meds a generic?
Yes, you receive a generic. Xtandi is the original brand, made by Astellas Pharma Europe B.V., and Direct Meds uses the name to identify the medicine; the generic has the same active ingredient (enzalutamide) at the same strength. The generic brand and manufacturer depend on available stock.
How is Xtandi priced?
Xtandi comes in a 40mg strength, in packs of 28 to 56 capsules, and the price of every option is shown above. Prices are set in US dollars and converted. Larger packs cost less per capsule.
Payment and prices →What is Xtandi used for?
Xtandi contains enzalutamide, used for prostate cancer.
Does Xtandi have side effects?
Yes. The common side effects of enzalutamide are fatigue, asthenia, hot flush, hypertension, falls and fracture. Less common ones include headache, dry skin, itching (pruritus), muscle spasms, back pain and haematuria. Serious but less common side effects include seizure, posterior reversible encephalopathy syndrome, myocardial infarction and ischaemic heart disease, which need urgent medical attention.
Which medicines interact with Xtandi?
Enzalutamide can interact with strong CYP2C8 inhibitors, CYP3A4 inducers, CYP3A4 substrates with narrow therapeutic index, CYP2C9 substrates with narrow therapeutic index, CYP2C19 substrates with narrow therapeutic index and warfarin. Tell your doctor or pharmacist about every medicine you take before you start taking Xtandi.
Can I buy Xtandi over the counter in South Africa?
Online, yes: Direct Meds does not ask for a prescription to order Xtandi. We are a broker, not a dispensing pharmacy. We arrange orders and delivery with our affiliated supplier on your behalf.
Ordering without a prescription →Where can I buy Xtandi in South Africa?
On Direct Meds: choose the strength and pack, then check out. Our affiliated supplier delivers across South Africa. Estimated delivery is 7 days with Express Delivery, which includes online tracking, or up to 3 weeks with Regular Delivery.
How ordering works →What you will receive
Xtandi names the medicine you are looking for. What ships is a generic version of it.
- A generic containing Enzalutamide at the strength you pick.
- Which generic brand and maker ships depends on stock and destination.
- Check the active ingredient, strength, form, pack, seal, batch and expiry when it arrives.