Xtandi
Enzalutamide capsules for prostate cancer. They block male hormones like testosterone from helping cancer grow.
- Category
- Prostate Health
- Active ingredient
- Enzalutamide
- Route
- Oral use
- Form
- Capsule, soft; Film-coated tablet
- Strengths
- 40mg
Xtandi is the reference name. You receive a generic with the same active ingredient and strength.
Supply requirements for Xtandi depend on the medicine and destination. The fulfilment partner must confirm them before accepting an order.
Xtandi details
- Condition
- Prostate Cancer
- Therapeutic class
- Hormone antagonists and related agents
- Pharmacological class
- Androgen receptor inhibitor
- Minor side effects
- fatigue; asthenia; hot flush; hypertension; falls; fracture
- Moderate side effects
- headache; dry skin; pruritus; muscle spasms; back pain; haematuria
- Dosage forms
- Capsule, soft; Film-coated tablet
- Administration route
- Oral use
- Supply category
- Prescription-only medicine (POM)
- Originator
- Astellas Pharma Europe B.V.
- Storage instructions
- This medicinal product does not require any special storage conditions.
Contraindications
hypersensitivity to enzalutamide or any excipients; women who are or may become pregnant
Precautions and warnings
risk of seizure; consider discontinuation if seizure occurs; posterior reversible encephalopathy syndrome has been reported; discontinue if confirmed; concomitant use with strong CYP2C8 inhibitors should be avoided or enzalutamide dose should be reduced; caution with CYP3A4, CYP2C9 or CYP2C19 substrates with narrow therapeutic index; ischaemic heart disease has been reported; falls and fractures reported; risk factors such as osteoporosis should be assessed; hypertension has been reported; blood pressure should be monitored; not to be handled by women who are or may become pregnant
Serious side effects
seizure, requires immediate medical attention; posterior reversible encephalopathy syndrome, requires immediate medical attention; myocardial infarction, requires immediate medical attention; ischaemic heart disease, requires immediate medical attention; severe hypersensitivity reaction, requires immediate medical attention
Patient summary
Enzalutamide capsules for prostate cancer. They block male hormones like testosterone from helping cancer grow.
Mechanism of action
Xtandi contains enzalutamide, a medicine that blocks the action of male hormones called androgens, including testosterone. Prostate cancer cells need androgens to grow. Enzalutamide works at multiple steps in the androgen receptor signalling pathway by preventing androgens from attaching to their receptors on cancer cells and blocking the receptors from sending growth signals to the cell nucleus. This helps slow the growth of prostate cancer and delay the spread of the disease.
Drug interactions
strong CYP2C8 inhibitors; CYP3A4 inducers; CYP3A4 substrates with narrow therapeutic index; CYP2C9 substrates with narrow therapeutic index; CYP2C19 substrates with narrow therapeutic index; warfarin; clopidogrel
Age restrictions
Not for use in children and adolescents. Safety and efficacy have not been established in paediatric population.
Pregnancy and breastfeeding
Pregnancy: Contraindicated in women who are or may become pregnant. Not indicated for use in women. May cause harm to the unborn child. Effective contraception required for male patients with female partners of childbearing potential. Breastfeeding: Confirm breastfeeding suitability with a qualified clinician or pharmacist before use.
What you will receive
Xtandi names the medicine you are looking for. What ships is a generic version of it.
- A generic containing Enzalutamide at the strength you pick.
- Which generic brand and maker ships depends on stock and destination.
- Check the active ingredient, strength, form, pack, seal, batch and expiry when it arrives.