Zofran
Ondansetron tablets for nausea and vomiting after chemotherapy or surgery. It blocks a chemical that triggers the vomiting reflex.
- Category
- Oncology Support
- Active ingredient
- Ondansetron
- Route
- Oral use
- Form
- Tablet
- Strengths
- 4mg · 8mg
Zofran is the reference name. You receive a generic with the same active ingredient and strength.
No prescription needed: we place your order for Zofran on your behalf.
- Alternative names
- ondansetron
- Therapeutic class
- 5-HT3 Receptor Antagonist
- Pharmacological class
- Antiemetic
- Known off-label uses
- gastroenteritis-associated vomiting
- Contraindications
- concurrent apomorphine use; hypersensitivity to ondansetron
- Minor side effects
- headache; constipation; fatigue
- Moderate side effects
- dizziness; mild rash; transient transaminase elevation
- Dosage forms
- Tablet
- Administration route
- Oral use
- Originator
- GlaxoSmithKline
- Onset Time
- 30–60 minutes
- Duration
- 8–12 hours
- Storage instructions
- Store below 25°C.
- Drug interactions
- Apomorphine; QT-prolonging drugs
- Age restrictions
- Approved for paediatric and adult populations based on formulation.
Serious side effects
QT prolongation, requires immediate medical attention; serotonin syndrome, requires immediate medical attention
Patient summary
Ondansetron tablets for nausea and vomiting after chemotherapy or surgery. It blocks a chemical that triggers the vomiting reflex.
Mechanism of action
Blocks peripheral and central 5-HT3 receptors on vagal nerve terminals and the chemoreceptor trigger zone in brain tissues.
Pregnancy and breastfeeding
Pregnancy: Suitability during pregnancy depends on the specific medicine and individual circumstances. Confirm with a qualified clinician or pharmacist before use. Breastfeeding: Consult a doctor.
Will I receive the original Zofran?
No. Zofran is the original brand, made by GlaxoSmithKline, and Direct Meds uses the name to identify the medicine: you receive a generic with the same active ingredient (ondansetron) at the strength you choose. The generic brand and manufacturer depend on available stock.
How much does Zofran cost in South Africa?
The price varies with strength and pack size. Zofran comes in 4mg and 8mg strengths, in packs of 60 to 360 tablets, and the price of every option is shown above in rand, converted from US dollars. Larger packs cost less per tablet.
Payment and prices →What is Zofran used for?
Zofran contains ondansetron, used for chemotherapy-induced nausea and vomiting and postoperative nausea and vomiting.
How quickly does Zofran work?
Ondansetron usually starts to work within 30 to 60 minutes, and its effect lasts about 8 to 12 hours. The exact timing differs between people.
What are the side effects of Zofran?
The common side effects of ondansetron are headache, constipation and fatigue. Less common ones include dizziness, mild rash and transient transaminase elevation. Serious but less common side effects include QT prolongation and serotonin syndrome, which need urgent medical attention.
What does Zofran interact with?
Ondansetron can interact with apomorphine and QT-prolonging drugs. Tell your doctor or pharmacist about every medicine you take before you start taking Zofran.
Do I need a prescription to buy Zofran in South Africa?
No, not online: Direct Meds does not ask for a prescription to order Zofran. We are a broker, not a dispensing pharmacy. We arrange orders and delivery with our affiliated supplier on your behalf.
Ordering without a prescription →Can I buy Zofran online in South Africa?
Yes. Our affiliated supplier delivers across South Africa. Estimated delivery is 7 days with Express Delivery, which includes online tracking, or up to 3 weeks with Regular Delivery.
How ordering works →What you will receive
Zofran names the medicine you are looking for. What ships is a generic version of it.
- A generic containing Ondansetron at the strength you pick.
- Which generic brand and maker ships depends on stock and destination.
- Check the active ingredient, strength, form, pack, seal, batch and expiry when it arrives.