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Amaryl (Glimepiride) Buyer and Patient Handbook in South Africa

Amaryl (glimepiride) is a sulfonylurea tablet used to improve blood-sugar control in adults with type 2 diabetes. It works by prompting the pancreas to release more insulin and is approved by the South African Health Products Regulatory Authority (SAHPRA). The medication is supplied as oral pills in strengths of 1 mg, 2 mg, and 4 mg.

Who Is Amaryl Intended For?

• Adults (≥ 18 years) diagnosed with type 2 diabetes who need additional glucose-lowering support.
• Patients whose blood-sugar targets are not met with lifestyle changes alone or with Metformin monotherapy.
• Individuals with normal kidney function (eGFR ≥ 30 mL/min/1.73 m²) and without a history of severe sulfonylurea reactions.

How Does Amaryl Work?

Amaryl belongs to the sulfonylurea class. It binds to the sulfonylurea receptor on pancreatic β-cells, causing a short-lasting surge of insulin secretion. The result is lower glucose levels after meals and throughout the day. Because it relies on the pancreas, it is ineffective in type 1 diabetes or advanced insulin-deficient states. The drug does not cause euphoria or a “high,” but taking more than prescribed can lead to dangerously low blood sugar.

Why Choose Amaryl?

• Proven efficacy: Clinical studies show consistent reductions in HbA1c when added to metformin.
• Convenient dosing: Once-daily tablet taken with breakfast simplifies routine.
• Cost-effective generic: Glimepiride is available as a generic tablet with the same bioavailability, offering a cheaper alternative without sacrificing quality.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• 1 mg once daily (starting dose for most patients).
• 2 mg once daily (if additional lowering is needed after 2-4 weeks).
• 4 mg once daily (maximum recommended dose).

How to Take

• Swallow the tablet whole with a full glass of water.
• Take it with the first main meal of the day to reduce the risk of hypoglycaemia.
• Do not crush or chew the tablet.

Missed Dose

• If you remember the missed dose within 12 hours, take it with the next meal.
• If more than 12 hours have passed, skip the missed dose and resume the regular schedule.

Overdose

• Call emergency services (dial 10111 in South Africa) immediately.
• If possible, give the patient a source of glucose (e.g., fruit juice) unless they are unconscious.

Special Populations

• Elderly: Start at 1 mg; monitor closely for low blood sugar.
• Renal impairment: Reduce to 1 mg daily when eGFR is between 30-45 mL/min/1.73 m²; avoid if below 30 mL/min/1.73 m².
• Pregnancy & breastfeeding: Use only if clearly needed and after discussion with a healthcare professional.

Lifestyle & Diet

• Avoid excessive alcohol: It can amplify the glucose-lowering effect and cause hypoglycaemia.
• Limit high-glycaemic foods: Pair the tablet with a balanced breakfast containing complex carbs, protein, and healthy fats.
• Grapefruit juice: No significant interaction, but maintain consistent intake to avoid fluctuations.

Precautions and Warnings

• Hypoglycaemia risk: Most common serious side effect; recognise symptoms (shakiness, sweating, confusion).
• Allergy: Do not use if you have a known sulfonylurea or sulfa-drug hypersensitivity.
• Cardiovascular disease: Use with caution; monitor blood pressure and lipid profile regularly.

Drug Interactions

Potential Side Effects

Common Side Effects

• Low blood sugar (hypoglycaemia)
• Headache
• Nausea

Less Common Side Effects

• Weight gain
• Dizziness
• Skin rash

Serious Side Effects

• Severe hypoglycaemia (loss of consciousness, Seizures) - seek medical help immediately
• Allergic reaction (swelling, difficulty breathing) - emergency care required

Who Should Avoid Amaryl?

• Individuals with a known allergy to glimepiride or other sulfonylureas.
• Patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²).
• Those with a history of recurrent severe hypoglycaemia.

Storage Instructions

• Keep the tablet in its original container, tightly closed.
• Store at room temperature (15-30 °C), away from direct sunlight and moisture.
• Keep out of reach of children and pets.

Amaryl Alternatives

Frequently Asked Questions

How quickly does Amaryl start to lower blood sugar?

It begins to work within 1-2 hours after taking the dose, with peak effect around 4-6 hours.

Can I take Amaryl if I drink coffee?

Yes, moderate coffee intake does not affect its action, but avoid excessive caffeine that may mask hypoglycaemia symptoms.

What should I do if I feel shaky after a dose?

These are classic signs of low blood sugar. Consume 15 g of fast-acting carbohydrate (e.g., glucose tablets, juice) and re-check your glucose after 15 minutes.

Is it safe to exercise while on Amaryl?

Regular aerobic activity is beneficial, but monitor blood sugar before, during, and after exercise to prevent hypoglycaemia.

Can I take Amaryl with other diabetes medicines?

It can be combined with metformin or SGLT2 inhibitors under professional guidance; always inform the clinician of all medicines you use.

How often should I have my blood sugar checked?

At least once daily when starting treatment, then weekly until stable, and thereafter as recommended by your care team.

What happens if I miss more than one dose?

Resume the regular schedule at the next meal; do not double-dose to catch up.

Will Amaryl cause weight gain?

Some patients experience modest weight gain due to increased insulin activity; a balanced diet and regular activity can mitigate this.

Glossary

• Sulfonylurea: A class of oral drugs that stimulate insulin release from the pancreas.
• Hypoglycaemia: Abnormally low blood glucose, often causing shakiness, sweating, and confusion.
• eGFR: Estimated glomerular filtration rate, a measure of kidney function.

Disclaimer

This handbook provides general information about Amaryl (glimepiride) and is not a substitute for professional medical advice. Off-label use should only be considered after consulting a qualified healthcare provider. The content is for educational purposes; readers are responsible for any health decisions they make. Our online pharmacy service offers a convenient way to obtain medicines, but you must verify that Amaryl is appropriate for you with a registered health professional.