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Jentadueto (Linagliptin; Metformin Hydrochloride) Buyer and Patient Handbook - South Africa

What is Jentadueto?

Jentadueto is a fixed-dose combination tablet that contains the two antidiabetic agents linagliptin and Metformin hydrochloride. It belongs to the DPP-4 inhibitor + biguanide class and is indicated for adults with type 2 diabetes when diet, exercise and metformin alone do not achieve adequate glycaemic control. The product is approved by the South African Health Products Regulatory Authority (SAHPRA) and is supplied as a 2.5 mg/100 mg tablet.

Who Should Use Jentadueto?

• Adults (≥ 18 years) with type 2 diabetes.
• Patients already taking metformin who need an additional DPP-4 inhibitor.
• Individuals whose blood sugar remains above target despite lifestyle measures.

How Does It Work?

Jentadueto tackles high blood sugar on two fronts: Linagliptin blocks the DPP-4 enzyme, which prolongs the action of incretin hormones that stimulate insulin release after meals. Metformin lowers glucose production in the liver and improves insulin sensitivity in muscle cells. Together they help keep blood sugar levels steady, much like a coordinated team that drives a car-one part accelerates while the other keeps the speed under control. Abuse potential is negligible, but patients should follow the prescribed dose.

Why Choose Jentadueto?

The combination offers convenient dosing (one pill instead of two separate tablets) and enhanced glycaemic control compared with metformin alone. As a branded product, it provides consistent tablet strength and quality assurance; generic alternatives containing the same ingredients are available for cost-conscious patients.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• One tablet (2.5 mg/100 mg) taken once daily.

How to Take

• Swallow the tablet whole with a full glass of water.
• Take it with your main meal to reduce gastrointestinal discomfort.

Missed Dose

• If you remember within 12 hours, take the missed tablet.
• Skip it if it’s almost time for the next dose; do not double-dose.

Overdose

• Seek immediate medical assistance.
• Symptoms may include nausea, vomiting, dizziness or severe lactic acidosis.

Special Populations

• Elderly: Start with the standard dose; monitor renal function.
• Renal impairment: Dose adjustment may be required; consult a healthcare professional.
• Pregnancy & breastfeeding: Use only if clearly needed; discuss risks with a clinician.

Lifestyle & Diet

• Avoid excessive alcohol, which can increase the risk of lactic acidosis.
• Grapefruit juice does not affect Jentadueto, but maintain a balanced diet and regular exercise.

Precautions and Warnings

• Monitor kidney function before starting and periodically during therapy.
• Watch for signs of lactic acidosis (muscle Pain, rapid breathing, abdominal discomfort).
• Do not use if you have a history of severe hypersensitivity to either component.

Drug Interactions

Potential Side Effects

Common Side Effects

• Nausea
• Diarrhoea
• Upper Respiratory Tract Infection

Less Common Side Effects

• Headache
• Dizziness
• Skin rash

Serious Side Effects

• Lactic acidosis (seek urgent care)
• Severe hypoglycaemia (especially if combined with insulin or sulfonylureas)
• Pancreatitis (persistent abdominal pain)

Who Should Avoid This Medication?

• Patients with known hypersensitivity to linagliptin, metformin, or any tablet excipients.
• Individuals with severe renal impairment (eGFR < 30 mL/min/1.73 m²) unless advised otherwise.
• Patients with acute or chronic metabolic acidosis, including diabetic ketoacidosis.

Storage Instructions

• Keep the bottle tightly closed.
• Store at room temperature, between 20 °C - 25 °C (68 °F - 77 °F).
• Protect from moisture and direct sunlight.
• Keep out of reach of children.

Jentadueto Alternatives

Frequently Asked Questions

How quickly does Jentadueto start to lower blood sugar?

Most patients notice a reduction in fasting glucose within 1-2 weeks; full effect may take up to 12 weeks.

Can I take Jentadueto if I have a mild kidney problem?

Mild to moderate renal impairment is usually acceptable, but kidney function should be evaluated before starting treatment.

Is it safe to drink coffee while on Jentadueto?

Yes, moderate coffee consumption does not affect the medication’s action.

What should I do if I experience persistent nausea?

Try taking the tablet with food; if nausea continues, discuss alternative dosing with a healthcare professional.

Does Jentadueto cause weight gain?

Weight gain is uncommon; some patients may experience modest weight loss due to improved glycaemic control.

Can I use Jentadueto together with a sulfonylurea?

Co-administration may increase hypoglycaemia risk; close monitoring of blood sugar is advised.

Will Jentadueto affect my cholesterol levels?

It has a neutral effect on lipids; any changes are usually unrelated to the drug.

How long can I stay on Jentadueto?

Treatment duration is individualized; many patients remain on it long-term as part of their diabetes management plan.

Glossary

• DPP-4 inhibitor: A drug class that blocks the enzyme dipeptidyl-peptidase-4, enhancing insulin release after meals.
• Biguanide: A class of oral antidiabetic agents, metformin being the most common, that reduces liver glucose production.
• Lactic acidosis: A rare but serious buildup of lactic acid in the body, requiring emergency medical care.

Disclaimer

The information presented here is for general educational purposes only and does not replace professional medical advice. Content is based on publicly available prescribing information and may not reflect the latest clinical guidelines. Off-label use should only be considered after consultation with a qualified healthcare provider. Our online pharmacy platform provides convenient access to approved medicines, but the ultimate responsibility for safe use rests with the patient. Always discuss any medication changes with a qualified clinician.