Entresto
Sacubitril and valsartan tablets for heart failure. They combine two actions to reduce strain on a failing heart.
All strengths and pack prices
| Strength | Pack | Price | Per unit |
|---|---|---|---|
| 24mg + 26mg | 56 tablets | $92.00 | $1.64 |
| 24mg + 26mg | 112 tablets | $136.00 | $1.21 |
| 24mg + 26mg | 168 tablets | $155.00 | $0.92 |
| 24mg + 26mg | 224 tablets | $186.00 | $0.83 |
| 24mg + 26mg | 280 tablets | $217.00 | $0.78 |
- Category
- Heart & Blood Pressure
- Active ingredients
- Sacubitril · Valsartan
- Route
- Oral use
- Form
- Tablet
- Strengths
- 24mg + 26mg
Entresto is the reference name. You receive a generic with the same active ingredient and strength.
No prescription needed: we place your order for Entresto on your behalf.
- Condition
- Heart Failure
- Alternative names
- sacubitril, valsartan
- Therapeutic class
- Neprilysin Inhibitor, Angiotensin II Receptor Antagonist Combination
- Pharmacological class
- Angiotensin Receptor-Neprilysin Inhibitor (ARNI)
- Contraindications
- history of angioedema; concurrent use of ACE inhibitors; pregnancy
- Minor side effects
- dizziness; cough; headache
- Moderate side effects
- hyperkalaemia; hypotension; renal impairment
- Serious side effects
- angioedema, requires immediate medical attention
- Dosage forms
- Tablet
- Administration route
- Oral use
- Originator
- Novartis
- Onset time
- 1–2 hours
- Duration
- 12 hours
- Storage instructions
- Store below 25°C.
- Drug interactions
- ACE Inhibitors; Lithium; Potassium Supplements
- Age restrictions
- Approved for paediatric and adult patients.
Patient summary
Sacubitril and valsartan tablets for heart failure. They combine two actions to reduce strain on a failing heart.
Mechanism of action
Sacubitril blocks neprilysin to raise vasoprotective peptides while valsartan blocks vasoconstricting AT1 receptors.
Pregnancy and breastfeeding
Pregnancy: High risk of fetal toxicity and death. Contraindicated in pregnancy. Breastfeeding: Not recommended.
FAQ
Is the Entresto on Direct Meds a generic?
Yes, you receive a generic. Entresto is the original brand, made by Novartis, and Direct Meds uses the name to identify the medicine; the generic has the same active ingredients (sacubitril and valsartan) at the same strength. The generic brand and manufacturer depend on available stock.
How is Entresto priced?
It depends on the pack size. Entresto comes in a 24mg + 26mg strength, in packs of 56 to 280 tablets, and the price of every option is shown above. Prices are set in US dollars and converted. Larger packs cost less per tablet.
Payment and prices →What other names is Entresto sold under?
In South Africa, sacubitril and valsartan are also sold under brand names such as Vymada.
What is Entresto used for?
Entresto contains sacubitril and valsartan, used for heart failure.
How quickly does Entresto work?
Sacubitril and valsartan usually start to work within 1 to 2 hours, and their effect lasts about 12 hours. This varies from person to person.
What are the side effects of Entresto?
The common side effects of sacubitril and valsartan are dizziness, cough and headache. Less common ones include hyperkalaemia, hypotension and renal impairment. Serious but less common side effects include angioedema, which needs urgent medical attention.
Which medicines interact with Entresto?
Sacubitril and valsartan can interact with ACE inhibitors, lithium and potassium supplements. Tell your doctor or pharmacist about every medicine you take before you start taking Entresto.
Can I buy Entresto over the counter in South Africa?
Online, yes: Direct Meds does not ask for a prescription to order Entresto. We are a broker, not a dispensing pharmacy. We arrange orders and delivery with our affiliated supplier on your behalf.
Ordering without a prescription →Can I buy Entresto online in South Africa?
Yes. Our affiliated supplier delivers across South Africa. Estimated delivery is 7 days with Express Delivery, which includes online tracking, or up to 3 weeks with Regular Delivery.
How ordering works →What you will receive
Entresto names the medicine you are looking for. What ships is a generic version of it.
- A generic containing Sacubitril / Valsartan at the strength you pick.
- Which generic brand and maker ships depends on stock and destination.
- Check the active ingredient, strength, form, pack, seal, batch and expiry when it arrives.