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Zyban (Bupropion) Buyer and Patient Handbook in South Africa

What is Zyban?

Zyban is a bupropion-based pill belonging to the atypical antidepressant class and is approved for Smoking Cessation. It helps people quit tobacco by reducing cravings and withdrawal symptoms. Zyban is FDA- and EMA-approved and available in a 150 mg tablet formulation in South Africa.

Who Should Use Zyban?

• Adults aged 18 years and older who want to stop smoking
• Individuals who have tried nicotine replacement therapy without success
• People without a history of Seizures or eating disorders

How Does It Work?

Zyban works by inhibiting the re-uptake of norepinephrine and dopamine, two brain chemicals involved in reward pathways. By keeping these neurotransmitters active longer, the medication lessens the urge to smoke, especially during stressful moments. It does not cause the “high” associated with recreational drugs, but misuse can lead to seizures in susceptible individuals.

Why Choose Zyban?

• Proven efficacy: Clinical trials show higher quit rates compared with placebo.
• Convenient dosing: Only a short-term pill regimen, no patches or inhalers required.
• Generic availability: Cost-effective alternative to brand-only products, while maintaining the same therapeutic effect.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• Start with 150 mg once daily for the first 3 days, then increase to 150 mg twice daily (morning and early afternoon) for a total of 7 weeks.

How to Take

• Swallow the tablet whole with a glass of water.
• Take Zyban after a meal to reduce stomach irritation.
• Keep a consistent schedule - the same times each day.

Missed Dose

• If you miss a dose, take it as soon as you remember provided at least 8 hours remain before the next scheduled dose.
• Skip the missed dose if it is almost time for the next one; do not double-dose.

Overdose

• Call emergency services (112 in South Africa) immediately if you suspect an overdose.
• Symptoms may include rapid heartbeat, seizures, or severe Agitation.

Special Populations

• Elderly: Start with a lower dose (150 mg once daily) and monitor for side effects.
• Renal impairment: Dose adjustment may be required; consult a healthcare professional.
• Pregnancy & breastfeeding: Use only if the benefit outweighs the risk, after professional advice.

Lifestyle & Diet

• Avoid excessive alcohol, as it may increase seizure risk.
• Grapefruit juice can raise bupropion levels; limit intake.
• Continue behavioral support (counselling, quit-lines) for best results.

Precautions and Warnings

• Do not use Zyban if you have a history of seizures, eating disorders, or are currently on MAO inhibitors.
• Monitor blood pressure regularly; Zyban can cause a modest rise.
• Report any new mood changes, Anxiety, or thoughts of self-harm promptly.

Drug Interactions

Potential Side Effects

Common Side Effects

• Dry mouth
• Insomnia
• Headache

Less Common Side Effects

• Tremor
• Nausea
• Weight loss

Serious Side Effects

• Seizures (seek urgent care)
• Severe rash or allergic reaction (stop medication, call emergency)
• Rapid heart rate or High Blood Pressure (consult a professional)

Who Should Avoid This Medication?

• Individuals with seizure disorders
• People with bulimia or Anorexia nervosa
• Patients currently taking MAO inhibitors (or within 14 days of stopping them)

Storage Instructions

• Store at 20-25 °C (68-77 °F), away from humidity.
• Keep the bottle tightly closed and out of reach of children.
• Do not freeze or expose to direct sunlight.

Zyban Alternatives

Frequently Asked Questions

How long does a typical quit-program with Zyban last?

The standard course is 7 weeks, followed by a tapering period if needed.

Can I drink coffee while taking Zyban?

Yes, moderate coffee intake is safe, but avoid excess caffeine if you notice increased jitteriness.

What should I do if I feel restless after the first dose?

Restlessness is common; try taking the tablet with food and ensure you get adequate sleep. If it persists, discuss dose timing with a healthcare professional.

Is Zyban safe for people with high blood pressure?

Zyban can raise blood pressure slightly; monitor readings regularly and inform a professional if they rise significantly.

Can I combine Zyban with nicotine gum?

Combining may increase stimulant effects; if needed, stagger the doses and monitor for rapid heartbeat.

How soon can I expect to notice a reduction in cravings?

Many users report decreased cravings within 3-5 days, but full benefits emerge over the first two weeks.

Are there any foods I must avoid while on Zyban?

Limit grapefruit juice and alcohol, as they can interfere with drug metabolism and increase seizure risk.

What happens if I stop Zyban abruptly?

Abrupt cessation may lead to rebound cravings; taper the dose under professional guidance for smoother discontinuation.

Glossary

• Norepinephrine: A neurotransmitter that regulates alertness and stress responses.
• Dopamine: A brain chemical involved in reward and motivation pathways.
• Seizure threshold: The level of neuronal excitability at which a seizure may occur; certain drugs can lower this threshold.

Disclaimer

This handbook provides general information only and is not a substitute for professional medical advice. Off-label uses are not endorsed; always consult a qualified healthcare provider before starting or changing any medication. Our service offers information and assistance in obtaining medicines legally; the ultimate responsibility for safe use rests with the patient.