Prograf
Tacrolimus capsules to stop organ transplant rejection. It suppresses the immune system's attack on the new organ and requires regular blood level checks.
All strengths and pack prices
| Strength | Pack | Price | Per unit |
|---|---|---|---|
| 0.5mg | 20 capsules | $113.00 | $5.65 |
| 0.5mg | 30 capsules | $164.00 | $5.47 |
| 0.5mg | 60 capsules | $301.00 | $5.02 |
| 0.5mg | 90 capsules | $406.00 | $4.51 |
| 0.5mg | 120 capsules | $502.00 | $4.18 |
| 0.5mg | 180 capsules | $692.00 | $3.84 |
| 0.5mg | 270 capsules | $949.00 | $3.51 |
| 0.5mg | 360 capsules | $1204.00 | $3.34 |
| 1mg | 10 capsules | $89.00 | $8.90 |
| 1mg | 20 capsules | $140.00 | $7.00 |
| 1mg | 30 capsules | $190.00 | $6.33 |
| 1mg | 60 capsules | $351.00 | $5.85 |
| 1mg | 90 capsules | $502.00 | $5.58 |
| 1mg | 120 capsules | $646.00 | $5.38 |
| 1mg | 180 capsules | $898.00 | $4.99 |
| 1mg | 270 capsules | $1244.00 | $4.61 |
| 1mg | 360 capsules | $1522.00 | $4.23 |
| 5mg | 10 capsules | $358.00 | $35.80 |
| 5mg | 20 capsules | $598.00 | $29.90 |
- Category
- Autoimmune Support
- Active ingredient
- Tacrolimus
- Route
- Oral use
- Form
- Capsule, hard
- Strengths
- 0.5mg · 1mg · 5mg
Prograf is the reference name. You receive a generic with the same active ingredient and strength.
No prescription needed: we place your order for Prograf on your behalf.
- Condition
- Organ Transplant Rejection
- Alternative names
- tacrolimus
- Therapeutic class
- Calcineurin Inhibitor
- Pharmacological class
- Immunosuppressant
- Known off-label uses
- severe active rheumatoid arthritis
- Contraindications
- hypersensitivity to tacrolimus
- Minor side effects
- headache; tremor; nausea
- Moderate side effects
- renal dysfunction; hypertension; hyperglycaemia
- Dosage forms
- Capsule, hard
- Administration route
- Oral use
- Originator
- Astellas Pharma
- Onset time
- 2–4 weeks
- Duration
- 12–24 hours
- Storage instructions
- Store below 25°C.
- Drug interactions
- Ketoconazole; Rifampin; Grapefruit
- Age restrictions
- Approved for children and adults under specialist care.
Serious side effects
severe nephrotoxicity, requires immediate medical attention; severe systemic infections, requires immediate medical attention
Patient summary
Tacrolimus capsules to stop organ transplant rejection. It suppresses the immune system's attack on the new organ and requires regular blood level checks.
Mechanism of action
Binds to intracellular immunophilins to block calcineurin, stopping critical T-cell transcription processes.
Pregnancy and breastfeeding
Pregnancy: Use if potential benefits justify risks. Breastfeeding: Contraindicated.
FAQ
Is the Prograf on Direct Meds a generic?
Yes, you receive a generic. Prograf is the original brand, made by Astellas Pharma, and Direct Meds uses the name to identify the medicine; the generic has the same active ingredient (tacrolimus) at the strength you choose. The generic brand and manufacturer depend on available stock.
How much does Prograf cost in South Africa?
Prograf comes in 0.5mg, 1mg and 5mg strengths, in packs of 10 to 360 capsules, and the price of every option is shown above. Prices are set in US dollars and converted. Larger packs cost less per capsule.
Payment and prices →What are the brand names for tacrolimus in South Africa?
In South Africa, tacrolimus is also sold under brand names such as Talomune, Advagraf and Graftac. On Direct Meds the same ingredient is also sold as Protopic.
What is Prograf used for?
Prograf contains tacrolimus, used for organ transplant rejection.
When does Prograf start working?
Tacrolimus usually starts to work within 2 to 4 weeks. The exact timing differs between people.
Does Prograf have side effects?
Yes. The common side effects of tacrolimus are headache, tremor and nausea. Less common ones include renal dysfunction, hypertension and hyperglycaemia. Serious but less common side effects include severe nephrotoxicity and severe systemic infections, which need urgent medical attention.
What does Prograf interact with?
Tacrolimus can interact with ketoconazole, rifampicin and grapefruit. Tell your doctor or pharmacist about every medicine you take before you start taking Prograf.
Can I buy Prograf over the counter in South Africa?
Online, yes: Direct Meds does not ask for a prescription to order Prograf. We are a broker, not a dispensing pharmacy. We arrange orders and delivery with our affiliated supplier on your behalf.
Ordering without a prescription →Where can I buy Prograf in South Africa?
On Direct Meds: choose the strength and pack, then check out. Our affiliated supplier delivers across South Africa. Estimated delivery is 7 days with Express Delivery, which includes online tracking, or up to 3 weeks with Regular Delivery.
How ordering works →What you will receive
Prograf names the medicine you are looking for. What ships is a generic version of it.
- A generic containing Tacrolimus at the strength you pick.
- Which generic brand and maker ships depends on stock and destination.
- Check the active ingredient, strength, form, pack, seal, batch and expiry when it arrives.