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Keflex (Cephalexin) Buyer and Patient Handbook - South Africa

What is Keflex?

Keflex is a tablet belonging to the cephalosporin antibiotic class, used to treat a range of bacterial infections such as skin infections, sore throat, ear infections, and urinary-tract infections. It is approved by the South African Health Products Regulatory Authority (SAHPRA) and also carries FDA and EMA clearance. The medication is supplied in 250 mg and 500 mg tablet strengths.

Who Should Use Keflex?

• Adults and adolescents (12 years and older) with confirmed or suspected bacterial infections that are susceptible to cephalexin.
• Patients who need a short-term oral antibiotic for uncomplicated infections.
• Individuals without a known allergy to penicillins or other cephalosporins.

How Does It Work?

Keflex interferes with the bacteria’s cell-wall synthesis, preventing the wall from forming correctly and causing the microbe to burst and die. Think of it as stopping a construction crew from finishing a building; without a complete wall, the structure collapses. This mode of action is bactericidal, meaning it kills the bacteria rather than merely inhibiting growth. Abuse potential is low, but unnecessary use can promote resistance, so it should only be taken when clearly indicated.

Why Choose Keflex?

• Proven efficacy: Cephalexin has decades of clinical use with a well-established safety profile.
• Convenient dosing: Once- or twice-daily tablets make adherence easier than many longer-acting antibiotics.
• Generic alternatives: If cost is a concern, generic cephalexin tablets provide the same therapeutic effect at a lower price.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• 250 mg tablet: 1-2 times per day, depending on infection severity.
• 500 mg tablet: 1-4 times per day as directed by a qualified health professional.

How to Take

• Swallow the tablet whole with a full glass of water.
• Can be taken with or without food; if stomach upset occurs, a small amount of food may help.

Missed Dose

• Take the missed dose as soon as you remember unless it is almost time for the next scheduled dose.
• Do not double-dose to make up for a forgotten tablet.

Overdose

• If you suspect an overdose, seek emergency medical attention immediately.
• Symptoms may include nausea, vomiting, Diarrhea, or dizziness.

Special Populations

• Elderly: Dose may be reduced if kidney function is impaired.
• Children (under 12 years): Use pediatric dosing guidelines; the tablets are not formulated for young children.
• Renal impairment: Adjust dose according to creatinine clearance; discuss with a pharmacist.

Lifestyle & Diet

• No major food interactions, but avoid excessive grapefruit juice as it can affect drug levels.
• Maintain adequate hydration to help the kidneys clear the medication.

Precautions and Warnings

• Do not use if you have a known allergy to cephalexin, other cephalosporins, or penicillins.
• Monitor for signs of Clostridioides difficile infection (persistent diarrhea, abdominal Pain).
• Use caution in patients with a history of renal disease; dose adjustment may be required.

Drug Interactions

Potential Side Effects

Common Side Effects

• Diarrhea
• Nausea or vomiting
• Stomach pain

Less Common Side Effects

• Rash or mild itching
• Headache
• Dizziness

Serious Side Effects

• Severe allergic reaction (hives, swelling, difficulty breathing) - seek immediate medical help.
• Persistent watery diarrhea or blood in stools - may indicate C. difficile infection; contact a health professional promptly.

Who Should Avoid This Medication?

• Anyone with a hypersensitivity to cephalexin or any cephalosporin.
• Patients with severe renal failure who cannot have dose adjustments.
• Individuals with a history of severe allergic reactions to penicillins (cross-reactivity possible).

Storage Instructions

• Store tablets at room temperature (15-30 °C).
• Keep the container tightly closed and protect from moisture and direct sunlight.
• Keep out of reach of children and pets.

Keflex Alternatives

Frequently Asked Questions

How long does a typical course of Keflex last?

Most uncomplicated infections are treated for 7-10 days, but the exact duration depends on the infection type and clinical response.

Can I drink coffee while taking Keflex?

Yes, moderate coffee consumption does not affect how Keflex works.

Is it safe to drink alcohol during treatment?

Alcohol does not interact directly with cephalexin, but excessive drinking may worsen side-effects such as stomach upset.

What if I don’t feel better after two days?

If symptoms persist or worsen after 48 hours, contact a health professional to reassess the infection.

Can Keflex be used for viral infections like the common cold?

No. Keflex treats bacterial infections only; it has no effect on viruses.

Does the tablet dissolve in water?

Keflex tablets are not formulated for oral suspension; they should be swallowed whole.

Will taking Keflex affect my blood test results?

It can cause a false-positive result for glucose in urine tests; inform the laboratory if you are on antibiotics.

Are there any activities I should avoid while on Keflex?

There are no specific activity restrictions, but if you experience dizziness, avoid driving or operating heavy machinery.

Glossary

• Cephalosporin: A group of antibiotics that disrupt bacterial cell-wall formation.
• Bactericidal: An agent that kills bacteria rather than merely stopping their growth.
• Clostridioides difficile: A bacterium that can cause severe diarrhea after antibiotic use.

Disclaimer

The information provided here is for general educational purposes only and does not replace professional medical advice. Keflex may be used off-label only under the guidance of a qualified health professional. Readers are responsible for verifying the suitability of any medication for their own health condition. Our online pharmacy platform offers convenient access to approved medicines, but you must consult a qualified practitioner before starting any new treatment.